Clinical diagnostic value of combined detection of inflammatory markers in pediatric bacterial pneumonia and mycoplasma pneumonia

Zhu Shunchao; Wang Mengqi; Xun Kongfu; Chen Sinong

doi:10.3969/j.issn.1674-7151.2025.04.015

Abstract：Objective To explore the clinical diagnostic value of combined detection of inflammatory markers in pediatric bacterial pneumonia and mycoplasma pneumonia.Methods The clinical data of 65 cases of pediatric bacterial pneumonia and 85 cases of mycoplasma pneumonia admitted to Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences from January 1 to August 31,2025 were collected.Additionally,16 cases with normal physical examination results were included as control group.The levels of serum procalcitonin(PCT),serum amyloid A(SAA)and blood C-reactive protein(CRP)were detected in all subjects,and the levels of above indicators among three groups were compared.Receiver operator characteristic curve(ROC curve)was plotted and area under ROC curve(AUC)was calculated to analyze the clinical values of inflammatory markers in assisting the diagnosis of pediatric bacterial pneumonia and mycoplasma pneumonia.Results The levels of SAA,CRP and PCT in bacterial pneumonia group were significantly higher than those in mycoplasma pneumonia group[SAA(mg/L):136.00(82.67,288.18)vs.19.70(10.4,49.65);CRP(mg/L):17.65(11.65,28.71)vs.3.05(1.11,7.17);PCT(μg/L):0.15(0.08,0.31)vs.0.08(0.05,0.15);all P<0.05].For distinguishing pediatric bacterial pneumonia from mycoplasma pneumonia,the AUC values of SAA,CRP and PCT were 0.912[95%confidence interval(95%CI)was 0.869-0.956],0.856(95%CI was 0.791-0.921)and 0.688(95%CI was 0.603-0.774),respectively.The AUC of combined detection of three indicators was 0.928(95%CI was 0.886-0.969).Conclusion PCT,SAA and CRP have high efficacies in distinguishing pediatric bacterial pneumonia from mycoplasma pneumonia,and they are of great significance for disease diagnosis.