Clinical value of Maitongning Decoction combined with low molecular weight heparin calcium for reducing formation of lower extremity deep vein thrombosis in patients with thoracolumbar fracture after surgery
Deng Xiaoyang
Huang Hongrui
Huang Wei
Abstract：Objective To investigate the preventive effect of Maitongning Decoction combined with low molecular weight heparin calcium on lower extremity deep vein thrombosis(DVT)in patients with thoracolumbar fracture after surgery and its impact on coagulation function.Methods A total of 60 patients with thoracolumbar fractures after surgery at the Second Affiliated Hospital of Guizhou University of Chinese Medicine from June 2024 to June 2025 were selected as research objects,and divided into control group(30 cases;treated with low molecular weight heparin calcium after surgery)and observation group(30 cases;received Maitongning Decoction in addition to control group).The incidence of lower extremity DVT,levels of coagulation function parameters[prothrombin time(PT),activated partial thromboplastin time(APTT)and D-dimer],lower extremity circumference difference and incidence of adverse reactions were compared between two groups.Results The incidence of lower extremity DVT in observation group was significantly lower than that in control group at 14 days postoperatively[6.67%(2/30)vs.26.67%(8/30),P<0.05].At 14 days postoperatively,the PT and APTT in observation group were significantly longer than those in control group,while the level of D-dimer and lower extremity circumference difference were lower than those in observation group[PT(s):14.82±1.26 vs.13.65±1.14;APTT(s):36.84±4.15 vs.33.27±3.86;D-dimer(mg/L):0.98±0.32 vs.1.57±0.45;thigh circumference difference(cm):1.05±0.43 vs.1.68±0.52;all P<0.05].There was no statistically significant difference in the incidence of adverse reactions between two groups[20.0%(6/30)vs.13.3%(4/30),P>0.05].Conclusions Maitongning Decoction combined with low molecular weight heparin calcium can effectively reduce the incidence of lower extremity DVT in patients with thoracolumbar fracture after surgery,improve coagulation function,and alleviate lower limb swelling,with good safety.It is worthy of promotion in clinical practice.
Keywords：Thoracolumbar fractureLower extremity deep vein thrombosisMaitongning DecoctionLow molecular weight heparin calciumCoagulation function
Publication Date：2025-12-30
Online Publishing Date：2026-02-02(First online date of this platform, not the publication date of the document)
Pages：4( 326-329 )