Effect of fiberoptic bronchoscopy bronchoalveolar lavage combined with rivastigmine on expression of inflammatory factors in lavage fluid of burn patients with inhalation injury
Liu Yunfeng
Sun Ran
Ding Sheng
Guo Zaiwen
Liu Xiaojun
Sun Bingwei
Abstract：Objective To analyze the therapeutic effect of fiberoptic bronchoscopy bronchoalveolar lavage combined with rivastigmine on burn patients with inhalation injury.Methods A total of 68 patients with burn combined with inhalation injury who received treatment in Suzhou Municipal Hospital were selected as research subjects.The time period of cases was from January 2022 to December 2024.Based on different treatment methods,the patients were divided into control group(33 cases;treated with conventional method)and study group(35 cases;treated with fiberoptic bronchoscopy bronchoalveolar lavage combined with rivastigmine).The changes in inflammatory indicators[interleukin(IL),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)]and coagulation parameters[D-dimer and fibrinogen(FIB)]before and after treatment were compared and analyzed between two groups.Results Compared with control group,the study group showed significantly shorter hospital stay and intensive care unit(ICU)stay[hospital stay(days):36.45±3.12 vs.40.45±3.90;ICU stay(days):7.02±2.01 vs.9.67±2.30;both P<0.05].After 1 week of treatment,the respiratory rate and heart rate in study group were significantly lower than those in control group,while oxygen saturation was significantly higher[respiratory rate(times/minute):22.60±1.01 vs.27.34±1.59;heart rate(beats/minute):98.40±2.56 vs.110.78±3.45;oxygen saturation:(97.68±5.71)%vs.(89.67±4.04)%;all P<0.05].After 1 week of treatment,the levels of related inflammatory and coagulation markers in study group were significantly lower than those in control group[IL-6(ng/L):26.64±1.60 vs.34.04±2.31;CRP(mg/L):5.45±2.31 vs.10.90±3.32;D-dimer(mg/L):1.28±0.54 vs.2.50±0.90;FIB(g/L):3.53±0.85 vs.4.08±0.94;all P<0.05].After treatment,the levels of TNF-α,IL-6 and IL-8 in bronchoalveolar lavage fluid(BALF)of study group were significantly lower than those in control group,while the level of IL-10 was significantly higher[TNF-α(ng/L):32.18±7.26 vs.45.21±9.43;IL-6(ng/L):65.27±12.98 vs.82.45±15.32;IL-8(ng/L):40.35±8.75 vs.54.37±10.21;IL-10(ng/L):33.72±6.84 vs.24.56±5.21;all P<0.05].The total effective rate in study group was significantly higher than that in control group[94.29%(33/35)vs.75.76%(25/33),P<0.05].Conclusions Treatment with fiberoptic bronchoscopy bronchoalveolar lavage combined with rivastigmine in patients with burn and inhalation injury could stabilize the condition more rapidly and improve the body's inflammatory state and coagulation disorder.
Keywords：BurnInhalation injuryFiberoptic bronchoscopy bronchoalveolar lavageRivastigmineInflammatory responseCoagulation disorder
Publication Date：2025-12-30
Online Publishing Date：2026-02-02(First online date of this platform, not the publication date of the document)
Pages：5( 321-325 )