Diagnositic value of fibrinolytic markers and systemic immune inflammation index for thromboembolism in patients with pulmonary cancer

Fu Chunhua; Zhong Changrui; Chen Meiying

doi:10.3969/j.issn.1674-7151.2025.04.007

Abstract：Objective To investigate the diagnostic value of fibrinolytic markers and systemic immune inflammation index(SII)for venous thromboembolism(VTE)in patients with lung cancer.Methods The clinical characteristics and laboratory data were collected and analyzed from 103 hospitalised patients with confirmed lung cancer admitted to Longyan Second Hospital,from 1 October,2023 to 1 October,2024.Among them,15 cases were diagnosed with VTE within 6 months after lung cancer diagnosis and were included in VTE group.The remaining 88 cases of lung cancer did not develop VTE after 6 months and were included in non-thrombosis group.Plasma levels of thrombomodulin(TM),thrombin-antithrombin Ⅲ complex(TAT),plasmin-α2-plasmin inhibitor complex(PIC),tissue plasminogen activator-inhibitor 1 complex(t-PAIC)and SII between two groups were compared.Receiver operator characteristic curve(ROC curve)was plotted and area under ROC curve(AUC)was calculated to analyze the diagnostic efficacy of above markers for thrombotic events.Results The levels of TM,TAT,PIC and SII in VTE group were significantly higher than those in non-thrombotic group,with all differences being statistically significant[TM(TU/mL):13.70(10.85,14.95)vs.10.20(9.75,11.52);TAT(μg/L):12.96(5.85,24.02)vs.5.99(3.38,11.12);PIC(mg/L):1.01(0.79,2.03)vs.0.85(0.54,1.12);SII(×109/L):1 060.71(559.63,2 506.98)vs.241.02(368.38,704.23);all P<0.05].The ROC curve showed that AUC of TM,TAT,PIC and SII were 0.811,0.704,0.666 and 0.811,and the AUC of combined application of TM and SII increased to 0.819,with 95%confidence interval(95%CI)of 0.689-0.943.Conclusions Patients with lung cancer and VTE exhibit heightened fibrinolytic activity.Early monitoring of fibrinolytic markers TM,TAT,PIC and SII may prevent thrombosis and reduce thrombotic complications.