Effect of Benazepril and Amlodipine Besylate on blood pressure and coagulation function in patients with primary hypertension

Jiang Longjiao

doi:10.3969/j.issn.1674-7151.2025.04.005

Abstract：Objective To explore the efficacy of combination of Benazepril and Amlodipine Besylate in patients with primary hypertension.Methods The 60 patients with primary hypertension who were admitted to Guizhou Panjiang Coal and Electricity Group Co.,Ltd.Hospital from January 2023 to December 2024 were selected as study subjects and divided into control group(30 cases;treated with Amlodipine Besylate)and observation group(30 cases;treated with Benazepril in addition to control group regimen).After one month of treatment,the total effective rates were compared between two groups.Blood pressure[diastolic blood pressure(DBP)and systolic blood pressure(SBP)]was measured using sphygmomanometer in both groups before and after treatment,coagulation indicators[activated partial thromboplastin time(APTT)and fibrinogen(FIB)]were detected using automatic blood coagulation analyzer,and adverse reactions were observed and recorded.Differences in the levels of above indicators between two groups before and after treatment were compared.Results The total effective rate in observation group was significantly higher than that in control group(96.67%vs.73.33%,P<0.05).After treatment,the levels of DBP,SBP and FIB in observation group were significantly lower than those in control group,while APTT was significantly longer than that in control group,with statistically significant differences[DBP(mmHg;1 mmHg≈0.133 kPa):80.23±3.07 vs.85.15±3.23;SBP(mmHg):121.30±3.09 vs.136.27±6.15;FIB(g/L):2.65±0.22 vs.3.32±0.38;APTT(s):36.53±2.87 vs.34.10±2.50;all P<0.05].There was no significant difference in the incidence of adverse reactions between observation group and control group(16.67%vs.10.00%,P>0.05).Conclusions The combination of Benazepril and Amlodipine Besylate in patients with primary hypertension helps to enhance the antihypertensive effect,more stably regulate blood pressure levels,and promote the repair and improvement of coagulation function in patients,with good safety.