Effect of meglumine cyelic adenosine injection combined with"Golden Triangle"regimen on cardiac function in patients with chronic heart failure

Xiao Chunlin

doi:10.3969/j.issn.1674-7151.2025.04.004

Abstract：Objective To explore the effect of meglumine cyelic adenosine injection combined with"Golden Triangle"regimen in the treatment of chronic heart failure(CHF).Methods A total of 88 patients with CHF admitted to Jiangle County General Hospital from January 2022 to February 2024 were selected as research subjects and randomly divided into combined treatment group(44 cases;receiving meglumine cyelic adenosine injection combined with"Golden Triangle"regimen)and conventional treatment group(44 cases;receiving"Golden Triangle"regimen).Cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)]were measured using ultrasound system.Inflammatory factors[interleukin-1β(IL-1β)and interleukin-18(IL-18)]and myocardial injury markers[N-terminal pro-brain natriuretic peptide(NT-proBNP)and cardiac troponinⅠ(cTnⅠ)]were measured using enzyme linked immunosorbent assay.The efficacy was assessed based on New York Heart Association(NYHA)cardiac function grading criteria,and adverse reactions such as gastrointestinal discomfort and hypotension were recorded.Results After treatment,the level of LVEF in combination treatment group was higher than that in conventional treatment group,while the levels of LVESD and LVEDD were lower than those in conventional treatment group[LVEF:(44.71±4.51)%vs.(40.91±4.02)%;LVESD(mm):35.01±3.61 vs.39.79±4.02;LVEDD(mm):45.02±4.61 vs.48.69±4.91;all P<0.05].After treatment,the levels of IL-1β,IL-18,NT-proBNP and cTnⅠ in combination treatment group were lower than those in conventional treatment group[IL-1β(ng/L):5.52±0.56 vs.6.43±0.63;IL-18(ng/L):214.64±22.02 vs.256.74±26.33;NT-proBNP(ng/L):381.64±37.26 vs.416.97±42.61;cTnⅠ(μg/L):1.52±0.16 vs.1.74±0.18;all P<0.05].The total effective rate of combination treatment group was higher than that of conventional treatment group(90.91%vs.75.00%,P<0.05),while the total incidence of adverse reactions showed no statistically significant difference between the two groups(15.91%vs.11.36%,P>0.05).Conclusions Meglumine cyelic adenosine injection combined with"Golden Triangle"regimen can significantly improve the cardiac function of patients with CHF,inhibit their inflammatory response and reduce myocardial damage,and the combined use of drugs does not significantly increase the adverse reactions of patients.