Clinical significance of continuous positive airway pressure treatment for non-arteritic anterior ischemic optic neuropathy combined with OSAHS
Zhang Xiaofei
Wang Yaoyong
Zhang Caiping
Abstract：Objective To investigate the clinical value of continuous positive airway pressure(CPAP)in treatment of non-arteritic anterior ischemic optic neuropathy(NAION)combined with moderate to severe obstructive sleep apnea hypopnea syndrome(OSAHS),and clarify its related therapeutic mechanism.Methods From June 2024 to May 2025,the 40 patients diagnosed with NAION combined with moderate to severe OSAHS in Shanxi Fenyang Hospital were selected for study,and divided into treatment group(20 cases;receiving conventional medication combined with CPAP)and control group(20 cases;receiving conventional medication).During the 30-day treatment period,the changes in core parameters such as nocturnal apnea hypopnea index(AHI),minimum oxygen saturation(MOS)and visual acuity and mean deviation(MD)of visual field in both groups were monitored and recorded.Results The total effective rate of treatment group was significantly higher than that of control group[90.0%(18/20)vs.30.0%(6/20),P<0.05].After treatment,the levels of AHI,MOS,MD and visual acuity in treatment group were significantly better than those before treatment[AHI(times/hour):3.5±1.8 vs.32.3±5.2;MOS:(92.5±3.2)%vs.(75.2±4.5)%;MD(dB):-10.3±3.2 vs.-17.5±5.8;visual acuity(LogMAR):0.32±0.13 vs.0.58±0.18;all P<0.05].After treatment,the levels of AHI,MOS,MD and visual acuity in treatment group were significantly better than those in control group[AHI(times/hour):3.5±1.8 vs.31.9±4.7;MOS:(92.5±3.2)%vs.(78.2±2.3)%;MD(dB):-10.3±3.2 vs.-16.3±3.5;visual acuity(LogMAR):0.32±0.13 vs.0.53±0.11;all P<0.05].Conclusions Adding CPAP treatment to conventional medication could more effectively manage NAION combined with moderate to severe OSAHS.Moreover,the nocturnal NAION symptoms in OSAHS patients are closely related to hypoxia,revealing that hypoxia may be the main cause of such lesions.
Keywords：Obstructive sleep apnea hypopnea syndromeContinuous positive airway pressureNonarteritic anterior ischmic optic neuropathyOxygen deficiency
Publication Date：2025-12-30
Online Publishing Date：2026-02-02(First online date of this platform, not the publication date of the document)
Pages：4( 300-303 )