Analysis on impact of plateletpheresis on platelet function of multiple blood donors

Yan Aimei; Jiang Haixia; Zhao Xue

doi:10.3969/j.issn.1674-7151.2025.03.018

Abstract：Objective To investigate the effect of plateletpheresis on platelet function in multiple blood donors.Methods A total of 50 voluntary blood donors who underwent plateletpheresis at Weifang Central Blood Station from January to December 2023 were selected as study subjects.The blood samples of study subjects were collected,the levels of platelet count(PLT),mean platelet volume(MPV)and platelet volume distribution width(PDW)were detected using fully automated blood analyzer,and the levels of prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)were detected using fully automated coagulation analyzer.The changes in platelet function indicators and coagulation function indicators of study subjects before the first plateletpheresis,after 6 months plateletpheresis and after 1 year the last plateletpheresis were compared.Results The levels of PLT,MPV and PDW before the first plateletpheresis were significantly lower than those after 6 months of plateletpheresis and after 1 year the last plateletpheresis,with statistically significant differences[PLT(×109/L):210.65±24.64 vs.232.48±30.92,259.42±38.71;MPV(fL):8.34±0.52 vs.9.45±0.64,10.17±0.80;PDW(fL):11.33±1.09 vs.13.28±1.40,15.31±1.56;all P<0.05],and the levels of PLT,MPV and PDW after 6 months plateletpheresis were significantly lower than those after 1 year the last plateletpheresis,with statistically significant differences(all P<0.05).There was no statistically significant difference in the levels of PT,TT,APTT and FIB among blood donors before the first lateletpheresis and after the last lateletpheresis[PT(s):12.65±0.44 vs.12.43±0.35;TT(s):16.70±1.31 vs.17.06±1.42;APTT(s):28.59±2.45 vs.29.03±2.55;FIB(g/L):3.22±0.31 vs.3.31±0.36;all P>0.05].Conclusion Although multiple plateletpheresis may lead to increase in platelet function indicators in blood donors,the levels of indicators are still within the normal reference range and will not have a significant impact on the platelet function and coagulation function of blood donors.