Predictive value of white blood cell classification count,coagulation indicators and hypersensitive C-reactive protein for adverse reactions of blood transfusion

Zheng Xiujin; Liu Chen

doi:10.3969/j.issn.1674-7151.2025.03.017

Abstract：Objective To investigate the predictive value of white blood cell classification count,coagulation indicators and hypersensitive C-reactive protein(hs-CRP)for adverse reactions of blood transfusion.Methods The clinical data of 60 patients who received blood transfusion in Fuzhou Changle District People's Hospital from January 1,2022 to December 31,2023 were reviewed and analyzed.Among them,30 patients with adverse reactions were included in study group,and 30 patients without adverse reactions were included in control group.The levels of white blood cell classification count[neutrophil count(NEU),eosinophil count(EOS)and basophil count(BAS)],hs-CRP and coagulation indicators[thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB)and prothrombin time(PT)]were compared between two groups before and after blood transfusion.Logistic multivariate regression analysis was used to evaluate the predictive value of above indicators for adverse reactions of blood transfusion.Results There were no significant differences in the levels of EOS,BAS,NEU,hs-CRP,FIB,TT,APTT and PT between two groups before blood transfusion.The levels of EOS,BAS,NEU,hs-CRP and FIB in two groups after blood transfusion were significantly higher than those before blood transfusion,and those in study group were significantly higher than those in control group[EOS(×109/L):0.36±0.13 vs.0.25±0.09;BAS(×109/L):0.31±0.10 vs.0.18±0.06;NEU(×109/L):7.20±1.90 vs.6.12±1.69;hs-CRP(mg/L):17.74±3.70 vs.9.64±2.73;FIB(g/L):4.02±0.68 vs.2.09±0.51;all P<0.05].The levels of TT,APTT and PT in two groups after blood transfusion decreased significantly,and those in study group were significantly lower than those in control group[TT(s):17.26±1.42 vs.19.13±1.69;APTT(s):28.38±3.69 vs.34.45±4.04;PT(s):11.85±2.70 vs.13.28±2.74;all P<0.05].Logistic regression analysis showed that the increase of NEU,hs-CRP and FIB levels and decrease of TT,APTT and PT levels were independent risk factors for adverse reactions[odds ratios(OR)were 1.517,1.237,2.846,1.465,1.340 and 1.397,respectively,and P values were 0.043,0.030,0.007,0.039,0.034 and 0.003].Conclusions The increase in NEU,hs-CRP and FIB levels,as well as decrease in TT,APTT and PT levels,are independent risk factors for adverse reactions of blood transfusion.White blood cell classification count,coagulation indicators and hs-CRP have important values in predicting transfusion adverse reactions.