Effect analysis on autologous blood transfusion in cardiac spinal surgery
Ma Fangfang
Chen Yanshuang
Xie Huabin
Cai Jinte
Abstract：Objective To explore the application effect of autologous blood transfusion in cardiovascular surgery,compare it with acute normovolemic hemodilution combined with intraoperative cell salvage technique,and evaluate the advantages of autologous blood transfusion in reducing postoperative bleeding,transfusion volume and adverse reactions.Methods The clinical data of 185 patients undergoing cardiovascular surgery in Affiliated Cardiovascular Disease Hospital of Xiamen University from January 2023 to December 2024 were retrospectively analyzed.According to different methods of blood transfusion,they were divided into autologous blood transfusion group(58 cases;acute normovolemic hemodilution combined with intraoperative recycled autologous blood transfusion),allogeneic blood transfusion group(60 cases;allogeneic blood transfusion according to the amount and composition of blood loss)and autologous+allogeneic blood transfusion group(67 cases;autologous blood transfusion combined with allogeneic blood transfusion).The blood routine indexes[hemoglobin(Hb)and hematocrit(Hct)],coagulation function indexes[activated partial thromboplastin time(APTT),prothrombin time(PT)and thrombin time(TT)]before and 24 hours after operation,as well as thoracic drainage volume and blood transfusion volume 24 hours after operation,postoperative adverse reactions and prognosis were compared.Results The levels of Hb and Hct in autologous blood transfusion group and autologous+allogeneic blood transfusion group were significantly higher than those in allogeneic blood transfusion group[Hb(g/L):128.41±13.74,102.28±14.72 vs.96.44±18.20;Hct:(38.74±3.73)%,(35.67±5.94)%vs.(30.50±4.77)%;all P<0.05].The PT,APTT and TT in autologous blood transfusion group were significantly shorter than those in allogeneic blood transfusion group[PT(s):12.76±1.27 vs.14.30±3.10;APTT(s):28.50±3.66 vs.36.96±11.87;TT(s):19.16±2.43 vs.24.45±19.84;all P<0.05].The thoracic drainage volume and blood transfusion volume 24 hours after operation in autologous blood transfusion group were significantly lower than those in allogeneic blood transfusion group[thoracic drainage volume 24 hours after operation(mL):220.0(150.0,322.5)vs.240.0(62.5,502.5);blood transfusion volume 24 hours after operation(mL):0(0,0)vs.0(0,273.5);both P<0.05].The incidence of adverse reactions and mortality in autologous blood transfusion group and autologous+allogeneic blood transfusion group were significantly lower than those in allogeneic blood transfusion group(incidence of adverse reactions:1.72%,1.49%vs.11.67%;mortality:1.72%,1.49%vs.3.33%;all P<0.05).Conclusions Autologous blood transfusion has significant clinical advantages in cardiovascular surgery,and could effectively reduce the incidence of postoperative anemia and promote the recovery of coagulation function.It also demonstrates notable benefits in reducing postoperative bleeding,volume of allogeneic blood transfusion,adverse reactions and improving overall patient outcomes.
Keywords：Cardiovascular surgeryAutologous blood transfusionAllogeneic blood transfusionAdverse reaction
Publication Date：2025-09-30
Online Publishing Date：2025-11-17(First online date of this platform, not the publication date of the document)
Pages：5( 246-250 )