Analysis on current status and risk factors of hyperuricemia in physical examination population of a certain region

Zhang Yanfei; Zhang Huiru; Guo Lefeng

doi:10.3969/j.issn.1674-7151.2025.03.008

Abstract：Objective To analyze the prevalence and population gender and age distribution of hyperuricemia(HUA)in Hohhot area,Inner Mongolia Autonomous Region,and explore the related risk factors.Methods A cross-sectional study was conducted on 11 807 physical examination patients in Inner Mongolia Maternal and Child Health Hospital from January to December 2024,including 5 299 males and 6 508 females.They were divided into≤20 years old group(82 cases),21-30 years old group(2 013 cases),31-40 years old group(3 550 cases),41-50 years old group(2 476 cases),51-60 years old group(2 354 cases),61-70 years old group(1 064 cases),71-80 years old group(234 cases)and≥81 years old group(34 cases).The clinical data were collected,including serum uric acid(UA),fasting blood glucose(FBG),total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C).The differences in UA abnormal rates,UA levels and HUA prevalence among different gender and age groups were analyzed.The patients were divided into HUA group(3 516 cases;UA>420 μmol/L in male and UA>357 μmol/L in female)and normal UA group(6 859 cases;UA 208-420 μmol/L in male and UA 149-360 μmol/L in female).The differences in UA,FBG,TC,TG,LDL-C and HDL-C between two groups were compared.Spearman correlation analysis was used to explore the correlation between HUA and biochemical indicators.Results In males,the level of UA was the highest in≤20 years old group and the lowest in≥80 years old group[(447.09±95.73)μmol/L and(342.86±102.11)μmol/L,respectively],and the UA level gradually decreased with age,with statistically significant differences.In females,the level of UA was the highest in 71-80 years old group and the lowest in 41-50 years old group[(329.94±85.29)μmol/L and(275.81±68.21)μmol/L,respectively],with statistically significant differences.Except for 41-50 years old group and 71-80 years old group,there were statistically significant differences in the detection rates of HUA between males and females in all other age groups,and there were also statistically significant differences in detection rates of HUA among different age groups of males and femals.The levels of TC,TG and LDL-C in HUA group were higher than those in normal UA group,while the level of HDL-C was lower than that in normal UA group[TC(mmol/L):4.96±1.07 vs.4.34±0.72;TG(mmol/L):2.38±1.28 vs.1.24±0.64;LDL-C(mmol/L):2.41±1.22 vs.1.07±0.25;HDL-C(mmol/L):2.27±1.12 vs.2.69±0.45;all P<0.05].Spearman correlation analysis showed that HUA was positively correlated with TC,TG and LDL-C,and negatively correlated with HDL-C(r values were 0.241,0.438,0.335,-0.221,P values were<0.001,<0.001,0.035,0.042,respectively).Conclusion The elevated UA levels in physical examination population of Hohhot are associated with gender,TC,TG,LDL-C and HDL-C,and preventive measures and dietary management should be strengthened.