Changes of RDW/ALB,NLR and ferritin and their relationship with pulmonary function in patients with chronic obstructive pulmonary disease
Li Caizhen
Abstract：Objective To explore the changes in levels of red blood cell distribution width to albumin ratio(RDW/ALB),neutrophil to lymphocyte ratio(NLR)and serum ferritin(SF)in patients with chronic obstructive pulmonary disease(COPD)and their correlation with pulmonary function.Methods A total of 100 patients with COPD admitted in Longyan People's Hospital and 100 healthy controls from January 2022 and October 2024 were enrolled as COPD group and control group,respectively.The levels of RDW/ALB,NLR,SF and pulmonary function indexes[vital capacity(VC),forced expiratory volume in 1 second to forced vital capacity ratio(FEV1/FVC)and peak expiratory flow(PEF)]were compared between the two groups.The relationship between RDW/ALB,NLR,SF and pulmonary function indexes was analyzed by Pearson correlation analysis.Receiver operator characteristic curve(ROC curve)was drawn and area under ROC curve(AUC)was calculated to analyze the diagnostic value of NLR,RDW/ALB,SF alone and in combination for COPD.Results The levels of NLR,SF and RDW/ALB in COPD group were higher than those in control group,while the levels of VC,FEV1/FVC and PEF were lower than those in control group[NLR:3.31±1.27 vs.1.94±0.63;SF(μg/L):284.56±121.35 vs.182.34±81.63;RDW/ALB:(1.35±0.24)%vs.(0.92±0.16)%;VC(L):1.93±0.31 vs.3.14±0.36;FEV1/FVC:(55.36±6.01)%vs.(79.86±7.24)%;PEF(L/s):3.42±0.79 vs.5.33±0.85;all P<0.05].The AUC of RDW/ALB combined with NLR and SF in diagnosis of COPD was 0.921,which was significantly greater than those of single indexes(which were 0.767,0.793 and 0.755,respectively;all P<0.05).The results of Pearson correlation analysis showed that RDW/ALB,NLR and SF were all negatively correlated with VC,FEV1/FVC and PEF(VC:r values were-0.402,-0.517,-0.461,all P<0.001;FEV1/FVC:r values were-0.416,-0.454,-0.508,all P<0.001;PEF:r values were-0.429,-0.554,-0.405,P values were<0.001,<0.001,0.003).Conclusions The combined detection of RDW/ALB,NLR and SF has higher diagnostic value in COPD.The levels of the above indexes are relatively higher in COPD patients,and are related to pulmonary function indexes.
Keywords：Chronic obstructive pulmonary diseaseRed blood cell distribution width to albumin ratioNeutrophil to lymphocyte ratioFerritinPulmonary functionDiagnostic value
Publication Date：2025-09-30
Online Publishing Date：2025-11-17(First online date of this platform, not the publication date of the document)
Pages：4( 215-218 )