Distribution and drug resistance analysis of pathogenic bacteria in elderly diabetic patients after abdominal surgery

Lin Lijun

doi:10.3969/j.issn.1674-7151.2025.03.004

Abstract：Objective To analyze the distribution and antimicrobial resistance of pathogens in postoperative infection among elderly diabetic patients.Methods A total of 100 elderly diabetic patients who developed postoperative infection after abdominal surgery in Zhangping General Hospital between December 2023 and December 2024 were selected as research objects.All patients underwent infection site sampling,microbial culture,standardized pathogen identification and antibiotic susceptibility testing upon hospital admission.The detection of pathogens in elderly diabetic patients with infection after abdominal surgery was counted,and the drug resistance of different types of pathogens was analyzed.Results Clinical specimens from 100 patients were examined,yielding 168 isolates including 109 strains of Gram negative(G-)bacteria(accouting for 64.88%)and 59 strains of Gram positive(G+)bacteria(accouting for 35.12%).G-pathogens predominantly consisted of Escherichia coli and Klebsiella pneumoniae,while G+pathogens were mainly Staphylococcus aureus and Enterococcus species.For primary G-bacterial species,the sensitive drugs were imipenem and amikacin.Escherichia coli and Klebsiella pneumoniae showed resistance rate of 0.00%to imipenem,while levofloxacin,cefotaxime and ciprofloxacin were the primary resistant drugs.Notably,both Escherichia coli and Klebsiella pneumoniae exhibited the highest resistance rates to levofloxacin at 58.33%and 64.29%,respectively.For primary G+bacterial species,vancomycin and linezolid were the primary sensitive drugs.Staphylococcus aureus and Enterococcus species showed resistance rate of 0.00%to vancomycin,linezolid and ticarcillin,while penicillin and tetracycline were the primary resistant drugs.Staphylococcus aureus and Enterococcus species demonstrated the highest resistance rates to penicillin at 84.00%and 85.71%,respectively.Conclusions In elderly diabetic patients undergoing abdominal surgery,G-bacteria are the main pathogens causing postoperative infections.Various common pathogens exhibit resistance to frequently used antimicrobials.Clinicians should select appropriate antimicrobials based on microbial susceptibility profiles to enhance surgical outcomes and promote favorable prognoses.