Characteristics of anti-nuclear antibody spectrum and clinical diagnostic analysis in patients with anti-centromere antibody positivity
Geng Yaping
Yin Chunqiong
Sun Jiqin
Dai Hongbin
Hu Ying
Abstract：Objective To explore the distribution of various antibodies in anti-nuclear antibody spectrum(ANAs)of patients with positive anti-centromere antibodies(ACA),the distribution in patients with different diseases,and their clinical application value.Methods The relevant laboratory test results and clinical data of 326 cases of ACA positive patients at the Second People's Hospital of Qujing from January 2016 to December 2023 were reviewed and analyzed.Results Among the 22 415 patients tested for anti-nuclear antibody(ANA),2 267 cases were positive(positive rate of 10.11%).Of these,326 cases were ACA positive,accounting for 14.38%of ANA positive patients and 1.45%of total tested population.There were 250 cases(76.69%)of single-type ACA and 76 cases(23.31%)of composite nuclear patterns,with the combination of granular and cytoplasmic granular patterns being the most common.Analysis of ANAs in ACA positive patients revealed that anti-CENP-B antibodies had the highest detectable rate(80.37%),followed by anti-RO-52 and anti-M2 antibodies,with mostly two or more antibodies simultaneously.Among the 326 cases of ACA-positive patients,84 cases(25.77%)had autoimmune diseases(AID)and 242 cases had non-AID.Conclusions Single-type ACA is common,and anti-CENP-B antibodies dominate the ANAs in ACA positive patients.ACA has diagnostic value for AID,particularly with a high detectable rate in primary biliary cirrhosis(PBC)patients.Among non-AID patients,detectable rates are relatively higher in liver diseases and lung infections,followed by hematological diseases,hypertension and diabetes.
Keywords：Anti-centromere antibodyAnti-nuclear antibody spectrumAutoimmune disease
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 166-168 )