Etiological characteristics and clinical significance of lower respiratory tract infection in department of respiratory medicine

Sun Qian; Xue Yanqiu

doi:10.3969/j.issn.1674-7151.2025.02.014

Abstract：Objective To analyze the etiological characteristics and clinical significance of lower respiratory tract infection in department of respiratory medicine.Methods The 325 patients with lower respiratory tract infection who were treated in respiratory medicine department of the Third Affiliated Hospital of Xuzhou Medical University from January 2023 to June 2024 were selected as research objects.All the patients received etiological characteristics analysis on admission,and the distribution and drug resistance of pathogens were counted.Results A total of 496 strains of pathogenic bacteria were detected in 325 patients with lower respiratory tract infection.Among them,351 strains(accounting for 70.77%)of Gram negative(G-)bacteria were detected,followed by 98 strains(accounting for 19.76%)of Gram positive(G+)bacteria,and 47 strains(accounting for 9.47%)of fungi were detected.The drug resistance rates of Staphylococcus aureus in G+bacteria to penicillin-based antibacterial drugs such as ampicillin,ampicillin/sulbactam and ticacillin/clavulanic acid were 17.24%,12.07%and 24.14%,respectively.The drug resistance rates of Streptococcus pneumoniae to penicillin-based antibacterial drugs such as ampicillin,ampicillin/sulbactam and ticacillin/clavulanic acid were 26.92%,19.23%and 26.92%,respectively.The drug resistance rates of Staphylococcus epidermidis to penicillin-based antibacterial drugs such as ampicillin,ampicillin/sulbactam and ticacillin/clavulanic acid were 30.00%,20.00%and 20.00%,respectively.Among them,Staphylococcus aureus and Streptococcus pneumoniae had the lowest drug resistance rates to ampicillin/sulbactam,and Staphylococcus epidermidis had the lowest drug resistance rates to ampicillin/sulbactam and ticacillin/clavulanic acid.The drug resistance rates of Pseudomonas aeruginosa among G-bacteria to gentamicin and cephalosporin antibacterial drugs such as cefazolin and cefepime were 27.41%,40.74%and 42.22%,respectively.The drug resistance rates of Klebsiella pneumoniae to gentamicin and cephalosporin antibacterial drugs such as cefazolin and cefepime were 19.15%,32.98%and 36.17%,respectively.Acinetobacter baumannii had a relatively high sensitivity rate,and the drug resistance rates to gentamicin and cephalosporin antibacterial drugs such as cefazolin and cefepime were 23.17%,34.15%and 36.59%,respectively.Among them,the resistance rates of Pseudomonas aeruginosa and Streptococcus pneumoniae to gentamicin were the lowest,and the resistance rate of Acinetobacter baumannii to imipenem was the lowest.The sensitivity rates of Candida albicans to various antibacterial drugs were relatively low,and the drug resistance rates were all 75%or above.Conclusions G-bacteria infection is common in lower respiratory tract infection in department of respiratory medicine,and this type of pathogen has good sensitivity to gentamicin and cephalosporin antibiotics,followed by G+bacteria,which has good sensitivity to penicillin antibiotics.Fungal infection is rare,but fungi have high resistance to a variety of antibiotics.