Clinical study and comparison on renal function indexes in patients with rheumatism-related diseases

Lu Haijing; Wang Jiawen; Zhan Shaoshuo

doi:10.3969/j.issn.1674-7151.2025.02.012

Abstract：Objective To study and compare the renal function indicators in 3 777 patients with rheumatism-related diseases.Methods A total of 3 777 patients diagnosed and treated in Quanzhou Orthopedic Hospital Affiliated to Fujian University of Traditional Chinese Medicine(outpatient and inpatient)from July to December 2023 were selected as study subjects,including 1 284 cases of gouty arthritis(GA),672 cases of rheumatoid arthritis(RA),1 347 cases of ankylosing spondylitis(AS),357 cases of osteoarthritis(OA),32 cases of undifferentiated spondyloarthritis(uSpA)and 85 cases of juvenile idiopathic arthritis(JIA).In addition,427 normal examinees during the same period were selected and included in control group.The renal function indicators were collected for all subjects,the level of cystatin C(CysC)was measured by latex immunoturbidimetry,the level of creatinine(Cr)was detected using sarcosine oxidase method,the level of blood urea nitrogen(BUN)was measured by UV-glutamate dehydrogenase method,and the level of uric acid(UA)was measured by uricase-peroxidase method.The patients with GA were divided into normal UA group(548 cases;males≤446 μmol/L,females≤350 μmol/L)and high UA group(736 cases;males>446 μmol/L,females>350 μmol/L)based on UA levels.The differences in abnormal rates of renal function indicators between patients with rheumatism-related diseases and control group,as well as patients with different diseases and GA patients with normal and abnormal UA levels were compared.Results The abnormal rates of CysC and UA in patients with rheumatism-related diseases were significantly higher than those in control group(CysC:18.27%vs.13.11%;UA:41.36%vs.28.34%;both P<0.05),and there were no statistically significant difference in the abnormal rates of Cr and BUN(Cr:3.87%vs.3.28%;BUN:17.13%vs.14.99%;both P>0.05).Among patients with rheumatism-related diseases,GA patients had the highest abnormal rates of CysC,Cr and UA(29.91%,8.57%and 57.32%,respectively),while OA patients had the highest abnormal rate of BUN(31.37%).There were no statistically significant differences in the abnormal rates of CysC,Cr and BUN between normal UA group and high UA group in GA patients(CysC:30.84%vs.29.21%;Cr:7.85%vs.9.10%;BUN:18.61%vs.18.07%;all P>0.05).Conclusions The abnormal rates of renal function indexes in patients with rheumatism-related diseases are significantly higher than those in healthy individuals,and the abnormal rates of renal function indicators in GA patients are significantly higher than those in patients with other types of diseases and normal physical examination subjects.Clinicians should pay attention to abnormal renal function indicators and provide timely treatment measures when diagnosing and treating patients with rheumatism-related diseases.