Clinical efficacy of viral inactivated plasmapheresis for acute-on-chronic liver failure and its effect on coagulation markers in patients
Li Feng
Abstract：Objective To investigate the therapeutic effects of virus inactivated plasmapheresis on patients with acute-on-chronic liver failure(ACLF)and its impact on coagulation indicators.Methods The clinical data of 84 cases of patients with ACLF admitted to Sinan County People's Hospital from January 2022 to January 2024 were retrospectively analyzed.According to different plasmapheresis types,the patients were divided into control group(routine frozen plasmapheresis)and observation group(virus inactivated plasmapheresis),with 42 cases in each group.The levels of coagulation indicators[including prothrombin time(PT)and activated partial thromboplastin time(APTT)]were detected using fully automated coagulation analyzer.The levels of inflammatory factors[including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),procalcitonin(PCT)and interleukin-6(IL-6)]and liver function indicators[including aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBil)and direct bilirubin(DBil)]were detected using fully automated biochemical analyzer.The differences in the levels of above indicators,total effective rate of treatment and the occurrence of adverse reactions between the two groups were compared.Results The total effective rate of observation group was significantly higher than that of control group[95.24%(40/42)vs.80.95%(34/42),P<0.05].The levels of PT,APTT,TNF-α,CRP,PCT,IL-6,AST,ALT,TBil and DBil in observation group were significantly lower than those in control group[PT(s):14.83±1.32 vs.16.77±1.45;APTT(s):22.65±2.07 vs.26.24±2.42;TNF-α(ng/L):101.35±8.42 vs.123.25±11.86;CRP(mg/L):22.04±4.55 vs.28.34±4.75;PCT(μg/L):0.58±0.13 vs.0.80±0.11;IL-6(pg/L):9.37±1.43 vs.12.42±2.81;AST(U/L):108.27±8.55 vs.125.46±12.65;ALT(U/L):144.29±13.58 vs.160.77±15.16;TBil(μmol/L):215.96±20.25 vs.239.18±21.38;DBil(μmol/L):120.12±10.74 vs.138.08±11.57;all P<0.05].No adverse reactions occurred during the treatment period in both groups.Conclusion Compared with routine frozen plasma,virus inactivated plasmapheresis therapy is more effective in treating patients with ACLF,improving coagulation function,promoting inflammation and liver function recovery,and is safe and effective.
Keywords：Acute-on-chronic liver failureViral inactivated plasmapheresisClinical efficacyCoagulation indexInflammation levelLiver function indexSafety
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 141-144 )