Value of serum anti Müllerian hormone combined with sex hormone binding globulin in differential diagnosis of polycystic ovary syndrome
Zou Jiabing
Cheng Ke
Liu Hongyun
Abstract：Objective To explore the value of serum anti Müllerian hormone(AMH)combined with sex hormone binding globulin(SHBG)in the differential diagnosis of polycystic ovary syndrome(PCOS).Methods The clinical data of 84 patients with PCOS and 39 patients with adult ovarian granulosa cell tumor(AGCT)from January 2021 to December 2023 were retrospectively analyzed.The levels of AMH and SHBG were determined by chemiluminescence method,and the levels of above indicators between two groups were compared.The multivariate Logistic regression model was applied to evaluate whether serum AMH and SHBG were the influencing factors for differential diagnosis of PCOS.The receiver operator characteristic curve(ROC curve)was drawn and the area under ROC curve(AUC)was calculated to evaluate the diagnostic efficacies of serum AMH and SHBG alone and in combination for PCOS.Results The levels of AMH and SHBG in PCOS group were lower than those in AGCT group[AMH(μg/L):14.05±3.65 vs.17.57±6.88;SHBG(nmol/L):40.44±18.34 vs.57.70±34.94;both P<0.05].Logistic regression analysis showed that AMH and SHBG were independent factors for the differential diagnosis of PCOS[odds ratios(OR)were 0.863 and 0.972,P values were both 0.001).The ROC curve analysis results showed that the AUC of combined detection of serum AMH and SHBG for diagnosis of PCOS was 0.736,which was higher than those of AMH and SHBG alone(0.651 and 0.630,respectively).Conclusion AMH and SHBG are effective in the differential diagnosis of PCOS and AGCT,and the combination of the two indicators could reduce misdiagnosis and improve the accuracy of differential diagnosis.
Keywords：Anti Müllerian hormoneSex hormone binding globulinPolycystic ovary syndromeAdult ovarian granulosa cell tumor
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 137-140 )