Application value of anti thyroglobulin antibody and anti thyroid peroxidase antibody tests in diagnosis of Graves'disease

Yu Zizhen

doi:10.3969/j.issn.1674-7151.2025.02.009

Abstract：Objective To explore the application value of anti thyroglobulin antibody(TGAB)and anti thyroid peroxidase antibody(TPOAb)tests in diagnosis of Graves'disease.Methods The 188 cases of patients with Graves'disease admitted in the Seventh Affiliated Hospital,University of South China from January to December 2024 were selected as research subjects and included in research group.In addition,72 healthy individuals who underwent physical examinations in the hospital during the same period were selected and included in healthy control group.The levels of TGAB and TPOAb in all research subjects were detected using magnetic particle chemiluminescence immunoassay and the levels of two indicators between two groups were compared.The correlation between TGAB and TPOAb in patients with Graves'disease was investigated using Pearson correlation analysis.The receiver operator characteristic curve(ROC curve)was drawn and the area under ROC curve(AUC)was calculated to evaluate the diagnostic efficacy of TGAB and TPOAb for Graves'disease.Results The levels of TGAB and TPOAb in research group were significantly higher than those in healthy control group[TGAB(kU/L):64.69(22.33,321.54)vs.1.43(0.90,3.99);TPOAb(kU/L):370.30(82.81,1 000.00)vs.6.55(4.30,7.55);both P<0.05].There was a significant positive correlation between TGAB and TPOAb in patients with Graves'disease(r=0.731,P<0.001).The combined detection of TGAB and TPOAb has the highest diagnostic efficacy for Graves'disease,with AUC of 0.929,the sensitivity was 98.40%,and the specificity was 73.61%.Conclusion There is a certain correlation between TGAB and TPOAb levels and the occurrence of Graves'disease,and the combined detection of two indicators has the highest diagnostic value for Graves'disease.