Assessment value of dual bone markers for osteoporosis risk in middle-aged and elderly women with type 2 diabetes mellitus

Niu Xiaofang; Wang Lijun; Zhu Tengfei; Song Xia

doi:10.3969/j.issn.1674-7151.2025.02.008

Abstract：Objective To investigate the application value of osteocalcin(OC)and total type Ⅰ collagen amino-terminal elongating peptide(t-P1NP)in the risk assessment of osteoporosis(OP)in middle-aged and elderly people.Methods The clinical data of 500 middle-aged and elderly women with type 2 diabetes mellitus(T2DM)admitted to endocrinology department of the First Hospital of Lanzhou University from April 2023 to June 2024 were retrospectively analyzed,and the patients were divided into bone abnormality group(346 cases)and normal bone group(154 cases)according to bone mineral density(BMD).Electrochemiluminescence was used to detect serum OC and t-P1NP,and the differences of above indexes between the two groups were compared.The sensitivity and specificity were calculated according to the formula of diagnostic test evaluation index.The receiver operator characteristic curve(ROC curve)was plotted,area under ROC curve(AUC)was calculated,and the diagnostic value of serum OC and t-P1NP alone and in combination for OP was analyzed.The Kappa consistency test was used to evaluate the consistency of serum OC,t-P1NP alone and in combination and BMD in diagnosis of OP.Results The serum levels of OC and t-P1NP in bone abnormality group were lower than those in normal bone group[OC(μg/L):12.42±0.45 vs.19.00±0.40;t-P1NP(μg/L):25.44±1.37 vs.47.35±3.82;both P<0.05].The sensitivity and specificity of serum OC and t-P1NP in diagnosis of OP in patients with T2DM were 91.3%and 95.5%,which were higher than those of OC and t-P1NP alone.The consistent κ values of serum OC,t-P1NP alone and in combination and BMD in diagnosis of OP were 0.753,0.560 and 0.833,respectively.The AUC of serum OC and t-P1NP in combination for diagnosis of OP was 0.884,which was higher than those of two indexes alone(0.870 and 0.742).Conclusions The development of OP could be understood by detecting the changes of serum OC and t-P1NP levels.Dual indicators are more conducive to early diagnosis and prognosis evaluation of patients in clinical practice.