Clinical characteristics and influencing factors of inpatients with type 2 diabetes mellitus complicated with metabolic associated fatty liver disease
Li Liping
Li Xiao'e
Li Yanying
Abstract：Objective To analyze the clinical characteristics and influencing factors of inpatients with type 2 diabetes mellitus(T2DM)complicated with metabolic associated fatty liver disease(MAFLD).Methods The 312 inpatients with T2DM in endocrinology department of Weishan County People's Hospital from October 2023 to October 2024 were selected as research objects.Based on abdominal ultrasound findings and diagnostic criteria,the patients were divided into T2DM-only group(186 cases)and T2DM+MAFLD group(126 cases).Clinical parameters including gender,age and body mass index(BMI)were compared between the two groups.Serum insulin(INS)and C-peptide were measured using chemiluminescence immunoassay,glycated hemoglobin(HbA1c)was determined by high-performance liquid ion-exchange chromatography,and fasting blood glucose(FBG),total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),urea(UR),creatinine(Cr),serum uric acid(SUA),hypersensitive C-reactive protein(hs-CRP),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and γ-glutamyl transferase(GGT)were analyzed using automated biochemical analyzer,and uric acid/creatinine ratio(SUA/Cr)was calculated.Binary Logistic regression analysis was performed to identify risk factors for T2DM complicated with MAFLD.Results The levels of BMI,INS,C-peptide,TC,TG,LDL-C,SUA,hs-CRP,ALT,AST,GGT and SUA/Cr in T2DM+MAFLD group were significantly higher than those in T2DM-only group[BMI(kg/m2):27.02±3.62 vs.23.87±3.75;INS(mU/L):7.72(5.13,11.89)vs.5.66(3.66,8.23);C-peptide(μg/L):1.62(0.99,2.35)vs.1.13(0.64,1.73);TC(mmol/L):5.11(4.22,5.83)vs.4.63(4.01,5.35);TG(mmol/L):1.87(1.19,3.07)vs.1.19(0.83,1.84);LDL-C(mmol/L):3.03(2.49,3.70)vs.2.27(2.17,3.26);SUA(μmol/L):276.00(232.00,347.00)vs.247.00(193.00,305.00);hs-CRP(mg/L):2.00(1.00,4.65)vs.1.20(0.70,3.25);ALT(U/L):24.00(18.00,40.00)vs.19.00(14.00,27.00);AST(U/L):20.00(16.00,27.00)vs.17.00(15.00,23.00);GGT(U/L):28.00(20.00,41.50)vs.18.00(13.00,26.00);SUA/Cr(%):5.29(4.15,6.75)vs.4.46(3.64,5.39);all P<0.05].The levels of age,HDL-C and UR were significantly lower than those in T2DM-only group[age(years):53.82±10.81 vs.57.60±11.99;HDL-C(mmol/L):1.22(1.09,1.36)vs.1.34(1.15,1.54);UR(mmol/L):4.90(4.30,5.90)vs.5.50(4.40,6.90);all P<0.05].There were no statistically significant differences in gender,FBG,HbA1c and Cr levels between the two groups.The results of binary Logistic regression analysis showed that BMI,TG,UA and ALT were all risk factors for T2DM combined with MAFLD[odds ratios(OR)were 1.251,1.519,1.022 and 1.039,respectively,and 95%confidence intervals(95%CI)were 1.101-1.421,1.083-2.131,1.003-1.042 and 1.002-1.077,all P<0.05].Conclusion Compared with patients with simple T2DM,patients complicated with MAFLD have higher BMI,more obvious insulin resistance and dyslipidemia,and are more likely to have liver damage and hyperuricemia.BMI,TG,UA and ALT are risk factors for T2DM complicated with MAFLD,and have important auxiliary value for the clinical diagnosis.
Keywords：Type 2 diabetes mellitusMetabolic associated fatty liver diseaseBody mass indexBlood lipidSerum uric acid
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 120-124 )