Analysis on detection results of tumor markers in physical examination population in a city
Zhao Qi
Hang Liwei
Yang Lei
Ren Gui'e
Abstract：Objective To investigate the levels and application value of tumor markers in population undergoing physical examinations in Ordos City,Inner Mongolia Autonomous Region.Methods The 11 765 cases from medical checkups conducted at Ordos Dongsheng District People's Hospital were selected as study objects.Among them,there were 4 262 males and 7 503 females,3 991 cases of 20-35 years old,4 637 cases of>35-50 years old,2 647 cases of>50-70 years old and 490 cases of>70 years old.The levels of alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153),carbohydrate antigen 199(CA199),carbohydrate antigen 724(CA724),ferritin(Fer),pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),gastrin-releasing peptide precursor(Pro-GRP),cytokeratin 19 fragment(CYFRA21-1),neuron-specific enolase(NSE),free prostatic specific antigen(fPSA)and total prostatic specific antigen(tPSA)were measured using fully automatic chemiluminescence immunoassay analyzer,and the abnormal detectable rates were evaluated.Furthermore,differences in the expression levels of genes related to the tumor markers in gastric cancer were examined using Gene Expression Profiling Interactive Analysis(GEPIA)database.Results The abnormal rates of CA125,CA199 and CA724 among females were significantly elevated compared to males(CA125:2.79%vs.0.00%;CA199:3.67%vs.2.90%;CA714:23.30%vs.20.79%;all P<0.05).The abnormal rates of CEA,Pro-GRP,NSE,PGⅠ and CYFRA21-1 in males were significantly higher than those in females(CEA:1.85%vs.0.37%;Pro-GRP:4.74%vs.2.08%,NSE:9.06%vs.6.69%;PGⅠ:28.70%vs.13.24%;CYFRA21-1:3.20%vs.1.63%;all P<0.05).All indicators in males of>70-year-old group exhibited the highest abnormal rates.Similarly,the abnormal rates of CEA,CA199,CA153,NSE,PGⅠ,Fer,CYFRA21-1 and Pro-GRP in females were also the highest in>70-year-old group.Analysis of the GEPIA database indicated that abnormalities in CEA,CA199,PGⅠ,PGⅡ,Pro-GRP and CYFRA21-1 were correlated with the incidence of gastric cancer,which suggested that deviations in the biomarkers might serve as potential indicators for the detection of gastric cancer.Conclusions The variations in levels of tumor markers across patients of varying genders and ages were found to be statistically significant.Furthermore,a comprehensive analysis of six tumor markers,including CEA,CA199,PGⅠ,PGⅡ,Pro-GRP and CYFRA21-1,could facilitate the early detection and treatment of gastric cancer.
Keywords：Tumor markerCarcinoembryonic antigenCarbohydrate antigenGene Expression Profiling Interactive Analysis database
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 110-115 )