Effect of repetitive transcranial magnetic stimulation therapy on cerebral blood flow circulation and cognitive function in patients with mild cognitive impairment after stroke

Xu Qingbin

doi:10.3969/j.issn.1674-7151.2025.02.003

Abstract：Objective To investigate the effects of repetitive transcranial magnetic stimulation(rTMS)therapy on cerebral blood circulation and cognitive function in patients with mild cognitive impairment after stroke.Methods The 106 patients with mild cognitive impairment after stroke admitted to Quanzhou First Hospital were selected as research objects,and the clinical data of patients were reviewed and analyzed.Among them,53 patients admitted from January to December 2022 were included into control group(receiving conventional drug treatment and cognitive function training),and 53 patients admitted from January to December 2023 were inluded into observation group(receiving rTMS therapy on the basis of control group).All study subjects were continuously intervened for 4 weeks.Before and after intervention,the cerebral blood circulation indicators in two groups were detected using cerebral vascular hemodynamic monitor,and cognitive function was evaluated using Montreal cognitive assessment scale(MoCA).The stroke specific quality of life(SS-QOL)scale was used to evaluate the patients'quality of life.Results After 4 weeks of intervention,the cerebral artery blood flow velocity in observation group was significantly higher than that in control group,and the vascular resistance was significantly lower than that in control group[arterial blood flow velocity(cm/s):40.52±4.76 vs.36.19±4.23;vascular resistance(Pa·s/L):1.60±0.21 vs.1.77±0.26;both P<0.05].The naming,attention,language,calculation,delayed memory,abstract summarization,visual space and execution,orientation scores in MoCA scale and SS-QOL score in observation group were significantly higher than those in control group[naming(points):2.65±0.20 vs.2.44±0.22;attention(points):5.62±0.17 vs.5.35±0.32;language(points):1.78±0.14 vs.1.63±0.11;calculation(points):2.70±0.10 vs.2.57±0.13;delayed memory(points):2.71±0.11 vs.2.50±0.23;abstract summary(points):1.80±0.09 vs.1.65±0.18;visual space and execution(points):4.78±0.15 vs.4.52±0.23;directional force(points):5.55±0.24 vs.5.10±0.36;SS-QOL(points):187.25±14.40 vs.172.46±16.37;all P<0.05].Conclusion rTMS therapy could effectively improve cerebral blood flow circulation,enhance cognitive function,and improve quality of life in patients with mild cognitive impairment after stroke.