Correlation analysis between levels of serum related indexes and degree of coronary artery stenosis in patients with coronary heart disease

Sun Peng; Cheng Xinyuan

doi:10.3969/j.issn.1674-7151.2025.02.002

Abstract：Objective To study the correlation of serum homocysteine(Hcy),cystatin C(CysC),C-reactive protein(CRP),creatine kinase isoenzyme(CK-MB),aspartate aminotransferase(AST)with the severity of coronary stenosis in coronary heart disease patients.Methods The 91 cases of coronary heart disease admitted in Bijie Hospital of Traditional Chinese Medicine during the period of April 2021 to April 2023 were taken as the subjects and included in the observation group.And 85 cases of healthy controls who received health examination over the same period were regarded as the control group.The venous blood samples from two groups of subjects were collected,a fully automated biochemical analyzer was used to detect the levels of Hcy,CysC,CRP,CK-MB and AST,and the differences between the two groups were compared.According to Gensini score of different degrees of coronary artery disease,the patients with coronary heart disease were divided into low-risk group(36 cases),medium-risk group(31 cases)and high-risk group(24 cases),and the differences in Hcy,CysC,CRP,CK-MB and AST levels among the groups were compared.Pearson correlation analysis was used to investigate the correlation between Hcy,CysC,CRP,CK-MB,AST and Gensini score.Results The levels of serum Hcy,CysC,CRP,CK-MB and AST in observation group were significantly higher than those in control group[Hcy(μmol/L):23.46±2.59 vs.8.77±1.36;Cys-C(mg/L):2.41±0.23 vs.0.74±0.10;CRP(mg/L):12.59±2.47 vs.5.31±0.89;CK-MB(U/L):30.94±5.31 vs.15.39±2.34;AST(U/L):51.46±6.77 vs.30.53±4.17;all P<0.05].The serum levels of Hcy,CysC,CRP,CK-MB and AST in high-risk group were significantly higher than those in medium-risk group and low-risk group[Hcy(μmol/L):32.88±4.05 vs.27.64±3.21,22.71±2.30;Cys-C(mg/L):3.86±0.65 vs.3.05±0.53,2.45±0.41;CRP(mg/L):19.75±3.26 vs.15.94±2.81,12.35±2.05;CK-MB(U/L):49.84±6.31 vs.40.66±5.21,30.75±4.89;AST(U/L):64.75±8.94 vs.58.94±7.57,52.36±7.01;all P<0.05].The levels of serum Hcy,CysC,CRP,CK-MB and AST in moderate-risk group were significantly higher than those in low-risk group(all P<0.05).The results of Pearson correlation analysis showed that Hcy,CysC,CRP,CK-MB and AST were positively correlated with Gensini scores(r values were 0.573,0.624,0.589,0.665 and 0.539,respectively,all P<0.001).Conclusion Serum Hcy,CysC,CRP,CK-MB and AST are all abnormally highly expressed in patients with coronary heart disease,and are positively correlated with the degree of coronary stenosis.