Research advances on application of neutrophil extracellular traps in patients with acute liver injury in intensive care unit
Zhang Yuye
Wang Xiaoyan
Han Xudong
Tian Lijun
Abstract：Neutrophil extracellular traps(NETs)are a kind of network structure formed by the modification of DNA cytoskeleton,histones and granule proteases,which are activated by neutrophils upon stimulation.The proper amount of NETs is a vital way for the body to remove pathogenic microorganisms,but excessive formation of NETs could damage normal tissues and further promote the development of disease.Acute liver injury(ALI)is a common organ injury in patients in intensive care unit(ICU),and the formation of NETs plays an important role in the development of ALI.This review explores and summarizes the formation mechanism and role of NETs,their role in ALI in ICU patients,and the mechanisms mediating several liver injuries,with a focus on potential treatment methods for NETs in ALI.
Keywords：Neutrophil extracellular trapIntensive care unitAcute liver injury
Publication Date：2025-03-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 81-86 )