A fatal case of metformin-associated lactic acidosis and literature review
Li Anming
Abstract：Objective To report a case of metformin-associated lactic acidosis(MALA)caused by high-dose metformin intake,and explore the clinical characteristics,diagnosis and treatment strategies.Methods On July 28,2024,a 67-year-old male patient with MALA due to excessive metformin intake was admitted to the emergency intensive care unit(EICU)at Chifeng Second Hospital.The patient's clinical data,diagnosis and treatment course were retrospectively analyzed.Results Despite aggressive interventions such as endotracheal intubation,invasive mechanical ventilation,vasoactive drug administration,massive sodium bicarbonate infusion and combined continuous renal replacement therapy,the patient ultimately died.Conclusions Early recognition,prompt discontinuation of metformin and aggressive symptomatic treatment are crucial for improving prognosis.Clinicians should strengthen their understanding of MALA,use metformin rationally,avoid overdose,and closely monitor high-risk patients.
Keywords：MetforminLactic acidosisMultiple organ damage
Publication Date：2025-03-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 74-77 )