Application effect and clinical value of transaminase detection in diagnosis of fatty liver

Cao Meifang

doi:10.3969/j.issn.1674-7151.2025.01.012

Abstract：Objective To explore and analyze the application effect and clinical value of transaminase detection in the diagnosis of fatty liver.Methods The 80 patients with fatty liver admitted to Zibo Municipal Hospital from April 2022 to April 2024 were selected as research subjects and included in fatty liver group,and 80 healthy individuals who underwent physical examinations during the same period were included into healthy control group.The levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were detected using rate method(RA),fully automated biochemical analyzer and transaminase detection kit.The differences in above indicators and elevation rates of transaminase between the two groups were compared.Based on the satisfaction questionnaire developed by the hospital,the patient satisfaction of fatty liver group was evaluated and recorded.Results The levels of AST and ALT in fatty liver group were significantly higher than those in healthy control group,and the differences were statistically significant[AST(U/L):46.10±10.15 vs.29.05±10.52;ALT(U/L):49.12±12.12 vs.22.11±13.23;both P<0.05].After treatment,the levels of AST and ALT in fatty liver group were significantly lower than those before treatment,and the differences were statistically significant[AST(U/L):31.56±11.00 vs.46.10±10.15;ALT(U/L):33.73±9.98 vs.49.12±12.12;both P<0.05].The elevation rates of AST and ALT in fatty liver group were significantly higher than those in healthy control group,and the differences were statistically significant[elevation rate of AST:70.00%(42/80)vs.2.50%(2/80);elevation rate of ALT:63.75%(51/80)vs.2.50%(2/80);both P<0.05].The overall patient satisfaction of fatty liver group was 90.00%(72/80),of which 64 cases(80.00%)were very satisfied,8 cases(10.00%)were relatively satisfied,and 8 cases(10.00%)were dissatisfied.Conclusions The detection of transaminase in diagnosis of patients with fatty liver has high clinical value,fast measurement rate,high accuracy and high patient satisfaction,which has good clinical application value.