Distribution characteristics and bacterial resistance analysis of positive pathogenic bacteria in pus culture of patients with perianal abscess

Zhang Zhongwen; Wang Juan; Chen Lingjuan

doi:10.3969/j.issn.1674-7151.2025.01.006

Abstract：Objective To investigate the distribution characteristics of positive pathogenic bacteria in pus culture of patients with perianal abscess,and analyze the drug resistance of bacteria.Methods The clinical data of 67 patients with perianal abscess admitted in Qingyuan People's Hospital from January 2021 to December 2023 were reviewed and analyzed.All patients underwent pathogen examination and susceptibility detection,and the distribution characteristics of positive pathogenic bacteria in pus culture and the drug resistance were analyzed.Results Among the 67 patients with perianal abscess,58 cases were Gram negative(G-)bacteria infection,mainly Escherichia coli(49 cases,accounting for 73.13%),and 9 cases were Gram positive(G+)bacteria infection,mainly Enterococcus faecalis,Streptococcus pyogenes,Staphylococcus aureus and Streptococcus pharyngitis.Escherichia coli was sensitive to amikacin,meropenem,piperacillin/tazobactam,cefoperazone/sulbactam,imipenem and colistin,and was highly resistant to ampicillin,piperacillin and tetracycline(the proportions of resistant strains were 85.71%,75.51%and 73.47%).Enterococcus faecalis was sensitive to teicoplanin and vancomycin and resistant to penicillin.Streptococcus pyogenes was resistant to erythromycin and clindamycin.Streptococcus constella was resistant to erythromycin(the proportion of resistant strains was 100.00%).G-bacteria such as Escherichia coli,Acinetobacter baumannii,Edwardsiella tarda and Klebsiella pneumoniae subsp.pneumoniae were sensitive to amikacin,meropenem and imipenem(only one strain of Escherichia coli showed resistance to imipenem).G+bacteria such as Enterococcus faecalis,Streptococcus pyogenes and Streptococcus pharyngitis were all sensitive to vancomycin(no resistant strain was detected).Conclusions The positive pathogenic bacteria in pus culture of patients with perianal abscess are mostly G-bacteria,among which Escherichia coli is the most common.Amikacin,meropenem and imipenem could be used as preferred drugs for G-bacterial infection in clinic,and vancomycin could be used as the preferred drug for G+bacterial infection.However,antibiotics still need to be reasonably selected based on drug sensitivity test results for subsequent treatment to reduce the production of multidrug-resistant strains.