Predictive value of blood uric acid combined with parathyroid hormone for heart failure within 1 year after PCI in patients with acute myocardial infarction

Lin Baozhu

doi:10.3969/j.issn.1674-7151.2025.01.003

Abstract：Objective To investigate the predictive value of blood uric acid(UA)and parathyroid hormone(PTH)for heart failure(HF)within 1 year after percutaneous coronary artery intervention(PCI)in patients with acute myocardial infarction(AMI).Methods The clinical data of 104 cases of AMI patients undergoing PCI in Longyan Traditional Chinese Medicine Hospital from November 2021 to November 2022 were reviewed and analyzed,and 53 patients with HF within 1 year after PCI were included in HF group.Using 6-minute walking distance as assessing criterion for HF severity,the patients with HF were divided into moderate to severe group(28 cases;0-450 m)and mild group(25 cases;>450 m),and the 51 patients without HF within 1 year after PCI were included in non-HF group.The differences in serum levels of UA,PTH,brain natriuretic peptide(BNP)and left ventricular ejection fraction(LVEF)at admission between two groups of patients and among HF patients of different severities were compared.The receiver operator characteristic curve(ROC curve)was drawn,the area under ROC curve(AUC)was calculated,and the predictive efficacy of above indicators for HF within 1 year after PCI in AMI patients was analyzed.Results In HF group,the level of LVEF was lower than that in non-HF group,and the levels of UA,PTH and BNP were higher than those in non-HF group[LVEF:(47.14±5.74)%vs.(51.13±6.15)%;UA(mmol/L):380.14±40.30 vs.363.98±35.20;PTH(ng/L):53.34±6.05 vs.50.78±5.32;BNP(ng/L):919.48±99.69 vs.879.31±101.50;all P<0.05].ROC curve analysis showed that the AUC of UA,PTH,LVEF and BNP for predicting HF within 1 year after PCI in AMI patients were 0.642,0.688,0.667 and 0.678,respectively.In moderate to severe group,the level of LVEF was higher than that in mild group,and the levels of UA,PTH and BNP were lower than that in mild group[LVEF:(49.53±7.03)%vs.(45.01±6.86)%;UA(mmol/L):369.35±34.71 vs.389.78±36.99;PTH(ng/L):51.56±5.93 vs.54.93±5.19;BNP(ng/L):889.83±95.62 vs.945.96±99.03;all P<0.05].Conclusion UA,PTH,BNP and LVEF could all predict the risk of postoperative HF within 1 year after PCI in AMI patients.