Correlation between detection of glycosylated hemoglobin combined with total bilirubin and type 2 diabetes mellitus complicated with coronary heart disease

Yu Haizhen; Liu Shanshan

doi:10.3969/j.issn.1674-7151.2024.04.016

Abstract：Objective To analyze the correlation between detection of glycosylated hemoglobin(HbA1c)combined with total bilirubin(TBil)and type 2 diabetes mellitus complicated with coronary heart disease.Methods The clinical data of 60 patients with type 2 diabetes mellitus complicated with coronary heart disease admitted in Zhucheng People's Hospital from May 2021 to May 2023 were reviewed and analyzed,and the patients were included in combined coronary heart disease group.The 60 patients with simple type 2 diabetes mellitus during the same time were included in simple diabetes group.Additionally,80 healthy individuals who underwent physical examinations during the same period were selected and included in healthy control group.Glucose oxidase method was used to detect blood glucose indicators[fasting blood glucose(FBG)and HbA1c],enzyme method was used to detect blood lipid indicators[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)]and uric acid(UA),and nitrophenylhydrazine method was used to determine TBil.Multivariate Logistic regression analysis was used to investigate the independent risk factors of type 2 diabetes mellitus complicated with coronary heart disease.Results The levels of FBG,HbA1c,TG,TC,LDL-C and UA in combined coronary heart disease group were significantly higher than those in simple diabetes group and healthy control group,and the levels of HDL-C and TBil were significantly lower than those in simple diabetes group and healthy control group[FBG(mmol/L):7.72±1.06 vs.6.55±0.74,5.51±0.64;HbA1c:0.078±0.006 vs.0.071±0.005,0.051±0.003;TG(mmol/L):2.56±0.34 vs.1.51±0.14,1.33±0.21;TC(mmol/L):4.81±0.52 vs.4.06±0.43,3.48±0.34;LDL-C(mmol/L):3.64±0.36 vs.2.93±0.24,2.62±0.17;UA(μg/L):448.64±71.58 vs.320.45±74.39,253.54±40.87;HDL-C(mmol/L):1.16±0.07 vs.1.33±0.08,1.45±0.13;TBil(mmol/L):7.81±0.73 vs.10.91±1.31,11.93±1.52;all P<0.05].The levels of FBG,HbA1c,TG,TC,LDL-C and UA in simple diabetes group were significantly higher than those in healthy control group(all P<0.05).Logistic regression analysis showed that the increased HbA1c level and decreased TBil level were independent risk factors for type 2 diabetes mellitus complicated with coronary heart disease[odds ratios(OR)were 1.781 and 0.592,95%confidence intervals(95%CI)were 1.047-3.146 and 0.345-0.872,both P<0.05].Conclusions The risk factors for type 2 diabetes mellitus complicated with coronary heart disease are increased HbA1c level and decreased TBil level.Therefore,the combined detection of HbA1c and TBil has practical value in the clinical diagnosis and treatment of type 2 diabetes mellitus complicated with coronary heart disease.