Diagnostic value of TyG-BMI index for nonalcoholic fatty liver disease in young people

Li Hongbo; Li Zhifeng

doi:10.3969/j.issn.1674-7151.2024.04.014

Abstract：Objective To explore the diagnostic value of the TyG-BMI index for nonalcoholic fatty liver disease(NAFLD)in young people.Methods The 1 658 fatty liver patients undergoing physical examinations at Physical Examination Center of Sihong Hospital from January 2020 to December 2022 were selected as research objects.Based on the severity of disease,they were divided into mild group(862 cases),moderate group(512 cases)and severe group(284 cases).Additionally,500 young adults without fatty liver during the same period were selected as control group.The results of triglyceride(TG),fasting blood glucose(FBG)and body mass index(BMI)of research objects were collected,and the triglyceride-glucose index(TyG)was calculated,followed by statistical analysis of TyG-BMI index.The abnormal rates of various indicators in patients with different disease severities were compared.The receiver operator characteristic curve(ROC curve)was drawn and the area under ROC curve(AUC)was calculated to evaluate the diagnostic efficacy of TyG-BMI index for mild NAFLD.Results The levels of TG,FBG,TyG and TyG-BMI index in mild,moderate and severe NAFLD groups were higher than those in control group[TG(mmol/L):1.12±0.49,1.20±0.52,1.32±0.65 vs.1.09±0.45;FBG(mmol/L):4.69±0.84,4.98±0.92,5.12±1.03 vs.4.61±0.78;TyG:8.62±0.12,8.78±0.15,8.89±0.20 vs.8.21±0.10;TyG-BMI index:192.1±14.2,212.5±15.3,223.5±18.6 vs.172.3±12.3;all P<0.05].As the severity of fatty liver increased,the abnormal rates of TG,FBG,TyG and TyG-BMI index increased,but the proportions of increase in TG and FBG were significantly lower than those of TyG and TyG-BMI index.The ROC curve analysis showed that AUC of TyG-BMI index was the largest at 0.896.When cutoff value was 195.60,sensitivity was 86.5%,and specificity was 81.2%.Comparing the diagnosis results of TyG-BMI index for mild NAFLD with the actual results,accuracy was 81.7%,and sensitivity reached 87.1%.Conclusion TyG-BMI index has important indicative significance in the occurrence and development of NAFLD in young people,and has certain predictive value for early onset of NAFLD in young people.