Correlation between GDF15 mRNA expression and glucose and lipid metabolism indexes in patients with gestational diabetes mellitus
Leng Li
Ma Lijuan
Bao Rui
Wang Ni
Guo Yuanyuan
Ding Rong
Abstract：Objective To analyze the correlation between the expression of growth differentiation factor-15(GDF15)mRNA and glucose and lipid metabolism indexes in pregnant women with gestational diabetes mellitus(GDM)in the second trimester.Methods The 100 patients in mid pregnancy(22-28 weeks)with GDM who underwent prenatal check-ups at the Second People's Hospital of Qujing from July,2022 to December,2023 were selected as research subjects and included in GDM group.Additionally,100 healthy pregnant women in mid pregnancy were selected as control group.The glucose and lipid metabolism indicators[fasting blood glucose(FBG),1-hour postprandial blood glucose(1hPG),2-hour postprandial blood glucose(2hPG),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]and GDF15 mRNA were detected in all subjects using chemical method and fluorescent quantitative PCR method.The differences in the levels of above indicators between two groups were compared.The correlation between GDF15 mRNA and FBG,1hPG,2hPG,TC,TG,HDL-C,LDL-C was investigated using Spearman correlation analysis.Results The levels of FBG,1hPG,2hPG,TC,TG,HDL-C and GDF15 mRNA in GDM group were higher than those in control group[FBG(mmol/L):5.12±0.43 vs.4.53±0.35;1hPG(mmol/L):9.33±1.67 vs.7.14±1.32;2hPG(mmol/L):8.19±1.57 vs.6.01±1.12;TC(mmol/L):4.50±1.31 vs.4.15±1.14;TG(mmol/L):2.42±0.95 vs.1.48±0.52;HDL-C(mmol/L):1.27±0.44 vs.1.14±0.37;GDF15 mRNA(copies/μL):6 348.00(2 547.00,13 035.00)vs.72.97(23.14,151.50);all P<0.05].The serum GDF15 mRNA in GDM group was positively correlated with FBG,1hPG,2hPG,TC,TG and HDL-C(r values were 0.571,0.552,0.590,0.151,0.521,0.193,P values were<0.001、<0.001、<0.001、0.037、<0.001、0.006).Multiple Logistic regression analysis showed that with the control group as a reference,the risk of abnormalities in one,two,and multiple indicators of glucose and lipid metabolism indicators increased as GDF15 mRNA level increased[odds ratios(OR)were 2.03,5.47 and 18.23,P values were 0.537,0.049 and<0.001].Conclusions The higher the expression of serum GDF15 mRNA,the higher the risk and severity of abnormal glucose and lipid metabolism in pregnant women.The detection of this indicator could effectively predict abnormal glucose and lipid metabolism during pregnancy.
Keywords：Gestational diabetes mellitusGrowth differentiation factor-15Glucose and lipid metabolism indicator
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 342-345 )