Distribution and influencing factors of vitamin D and vitamin K2 in hospitalized type 2 diabetes patients
Li Xiao'e
Hua Chunshan
Tang Qiaozhen
Pang Juanjuan
Wu Jiayun
Li Liping
Li Zhongchuan
Liu Mei
Abstract：Objective To explore the distribution and influencing factors of vitamin D(VitD)and vitamin K2(VitK2)and the correlation with metabolic indicators in patients with type 2 diabetes mellitus(T2DM).Methods The clinical data of 344 hospitalized T2DM patients in Weishan County People's Hospital from April 2021 to April 2023 were reviewed and analyzed.The levels of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A1(APOA1),VitD,VitK2,serum creatinine(SCr),uric acid(UA),globulin(GLO),albumin(ALB),total bile acid(TBA),thyroid stimulating hormone(TSH),free thyroxine(FT4)and glycated hemoglobin(HbA1c)were detected.The distribution of VitD and VitK2 in T2DM patients was analyzed,the multiple linear regression analysis was applied to explore the influencing factors,and the correlation with metabolic indicators was analyzed by Spearman correlation analysis.Results Among 344 hospitalized T2DM patients,87 cases(25.29%)had suitable VitD and 57 cases(16.57%)had suitable VitK2.In male,VitD was negatively correlated with FT4(r=-0.222,P=0.003)and positively correlated with TG and ALB(r=0.157,0.381;P=0.032,<0.001),VitK2 was negatively correlated with age(r=-0.243,P<0.001)and positively correlated with TG and TBA(r=-0.354,0.257;P<0.001,=0.001).In female,VitD was positively correlated with body mass index(BMI)and ALB(r=0.247,0.197;P=0.018,0.020),VitK2 was positively correlated with TG and TBA(r=0.333,0.296;P<0.001,=0.001).In hospitalized T2DM patients,the factors affecting VitD included BMI,FT4,ALB and gender,and the factors affecting VitK2 were TG,TBA and gender.Conclusions VitD and VitK2 are generally insufficient in hospitalized T2DM patients,with female being more pronounced than male.BMI and ALB are favorable factors for VitD,and TG and TBA are favorable factors for VitK2.
Keywords：Vitamin DVitamin K2Type 2 diabetes mellitusDistributionCorrelation
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 337-341 )