Clinical value of urinary NAG and microalbumin detection in monitoring early renal injury combined with urinary calculi

Wang Guilin

doi:10.3969/j.issn.1674-7151.2024.04.009

Abstract：Objective To analyze the clinical value of detection of urinary N-acetylβ-D-glucosaminidase(NAG)and microalbumin(mALB)in monitoring of early renal injury combined with urinary calculi.Methods The 100 patients with urinary calculi admitted to Pucheng County Hospital from February 2021 to February 2023 were selected as research subjects.They were divided into comorbidity group(40 cases)and no comorbidity group(60 cases)based on whether they had early kidney injury.The level of urinary NAG was detected using nitrobenzene substrate colorimetric method,and the level of urinary mALB was detected using immunoturbidimetric method.To reduce the impact of urine concentration or dilution on the detection results,creatinine(Cr)was simultaneously detected in all urine samples,and NAG/Cr and mALB/Cr ratios were calculated.The differences in levels of urine NAG,mALB,Cr,and NAG/Cr,mALB/Cr ratios were statistically analyzed between two groups,and the positive rates of urine NAG and mALB detected separately and in combination were compared in comorbidity group.Results The levels of urinary NAG,mALB,Cr and NAG/Cr,mALB/Cr ratios in comorbidity group were significantly higher than those in no comorbidity group[NAG(U/L):9.51±1.34 vs.7.90±1.10;mALB(mg/L):154.42±9.45 vs.39.06±6.32;Cr(mol/L):8.22±1.50 vs.3.25±1.02;NAG/Cr(U/mol):1.40±0.15 vs.1.07±0.31;mALB/Cr(mg/mol):21.75±3.75 vs.5.37±1.35;all P<0.05].The positive rate of combined detection of urinary NAG and mALB in comorbidity group was significantly higher than those of individual detection[90.00%(36/40)vs.75.00%(30/40),67.50%(27/40),both P<0.05].Conclusion Urinary NAG and mALB could both be used as sensitive indicators in monitoring of early renal injury combined with urinary calculi,and the clinical value of combined detection is higher than that of individual detection.