Changes and clinical significance of serum levels of CRP,PCT and IL-6 in patients with lower respiratory tract infection caused by Mycoplasma pneumoniae
Xu Xueqin
Huang Yanyun
Wu Haixia
Li Xuehua
Abstract：Objective To investigate the changes and clinical significance of serum levels of CRP,PCT and IL-6 in patients with lower respiratory tract infection caused by Mycoplasma pneumoniae.Methods Fifty patients with lower respiratory tract infection caused by Mycoplasma pneumoniae admitted in People's Hospital of Yuancheng District,Heyuan City from May 2023 to May 2024 were selected as research subjects and included in experimental group,and the patients in experimental group were divided into mild group(35 cases)and severe group(15 cases)based on the severity of their condition.Other fifty patients who participated in health examinations during the same period were included in control group.Electrochemiluminescence immunoassay was used to detect the level of interleukin-6(IL-6),immunoturbidimetry was used to detect the level of C-reactive protein(CRP),and electrochemiluminescence immunoassay was used to detect the level of procalcitonin(PCT).The differences in the levels of above indicators between experimental group and control group,and among patients with different severity levels of lower respiratory tract infection caused by Mycoplasma pneumoniae were compared.Results The levels of CRP,PCT and IL-6 in experimental group were significantly higher than those in control group[CRP(mg/L):8.17±0.94 vs.3.52±0.44;PCT(ng/L):2.04±0.34 vs.0.45±0.11;IL-6(μg/L):49.42±5.45 vs.21.36±2.58;all P<0.05].The levels of CRP,PCT and IL-6 in severe group were significantly higher than those in mild group[CRP(mg/L):8.27±0.92 vs.7.24±0.76;PCT(ng/L):2.14±0.26 vs.1.95±0.21;IL-6(μg/L):50.59±5.67 vs.43.25±4.67;all P<0.05].Conclusions The detection of CRP,PCT and IL-6 levels in patients with lower respiratory tract infection caused by Mycoplasma pneumoniae could provide certain reference for disease diagnosis and severity evaluation,and is worthy of clinical promotion and application.
Keywords：Lower respiratory tract infectionMycoplasma pneumoniaeC-reactive proteinProcalcitoninInterleukin-6
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 307-310 )