Effects of Bailing Capsule combined with doxofylline on arterial blood gas indexes and expression of inflammatory factors in COPD patients with type Ⅱ respiratory failure

Que Limei; Zhang Cuijing; Ma Yilong

doi:10.3969/j.issn.1674-7151.2024.04.002

Abstract：Objective To explore the effects of Bailing Capsule combined with doxofylline on arterial blood gas indexes and expression of inflammatory factors in patients with chronic obstructive pulmonary disease(COPD)and type Ⅱ respiratory failure.Methods A total of 80 patients with COPD and type Ⅱrespiratory failure treated in Longyan People's Hospital from March 2022 to March 2024 were selected as study objects and divided into control group and observation group according to different treatment methods,with 40 cases in each group.Both groups were given routine basic treatment,the patients in control group were given doxofylline orally,and those in observation group were given Bailing Capsule on the basis of control group.The total effective rate,complication rate,pulmonary function indexes[forced expiratory volume in the first second(FEV1),forced vital capacity(FVC)and FEV1/FVC],arterial blood gas indexes[arterial oxygen saturation(SaO2),arterial partial pressure of carbon dioxide(PaCO2)and arterial partial pressure of oxygen(PaO2)]and inflammatory factors[chemokine 12(CXCL12),tumor necrosis factor-α(TNF-α)and monocyte chemokine protein-1(MCP-1)]before and after treatment were compared between two groups.Results The total effective rate of observation group was higher than that of control group[92.50%(37/40)vs.75.00%(30/40),P<0.05].The pulmonary function indexes of both groups after treatment were better than those before treatment,and the levels of FEV1,FVC and FEV1/FVC in observation group were higher than those in control group[FEV1:(65.39±5.38)%vs.(60.15±4.20)%;FVC(L):2.43±0.65 vs.2.11±0.40;FEV1/FVC:(65.24±5.20)%vs.(60.74±3.19)%;all P<0.05].After treatment,the levels of SaO2 and PaO2 in observation group were higher than those in control group,and the level of PaCO2 was lower than that in control group[SaO2:(93.57±12.70)%vs.(82.11±10.36)%;PaO2(mmHg):74.20±5.72 vs.63.57±4.28,1 mmHg≈0.133 kPa;PaCO2(mmHg):42.04±5.25 vs.50.43±7.16;all P<0.05].Compared with control group,the levels of serum CXCL12,TNF-α and MCP-1 in observation group after treatment were decreased[CXCL12(ng/L):229.12±8.24 vs.242.74±10.29;TNF-α(pg/L):18.50±2.73 vs.26.73±3.11;MCP-1(ng/L):103.78±9.42 vs.120.14±11.63;all P<0.05].There was no significant difference in the incidence of complications between two groups.Conclusiosn Bailing Capsule combined with doxofylline is effective in the treatment of COPD with type Ⅱrespiratory failure,which could promote the patients'recovery of lung function,improve arterial blood gas indexes,and reduce inflammation.