Diagnosis of sepsis-induced coagulopathy and research advances in biomarkers
Liu Yiwen
Li Xu
Abstract：Objective Currently,it has been known that sepsis-induced coagulopathy(SIC)develops from the immunothrombosis which happens at the early stage of sepsis.Thrombosis and inflammation interact in the body and form a vicious cycle,jointly leading to the deterioration of the disease.SIC has different characteristics at different stages of the disease,which is reflected in the differences of coagulation-related indicators in clinical practice.Determining the stage of coagulopathy that the patient is in could assist doctors in providing precise treatment for each patient.At present,there are different diagnostic criteria for the early diagnosis of SIC.When using different criteria to diagnose,the specificity and sensitivity are varied.Currently,there are also researches on detecting new biological markers for SIC,with the aim of being able to diagnose the stage of intravascular coagulation early and precisely,so that corresponding treatments could be carried out in clinical practice.This review is about the inflammatory-immune interaction mechanisms of SIC,the advantages and disadvantages of commonly used international diagnostic criteria,and potential future prognostic indicators,focusing on four aspects such as the pathophysiological mechanisms of SIC,the importance of early recognition,diagnostic criteria for SIC and disseminated intravascular coagulation(DIC),and related cutting-edge indicators for early recognition of SIC.The aim is to organize,summarize and provide insights into the diagnosis and treatment of SIC based on clinical needs.
Keywords：Sepsis-induced coagulopathyDiagnosisBiological marker
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 289-294 )