Correlation between glycolipid metabolism indexes and gestational diabetes mellitus in pregnant women

Lin Lianyun; Mei Suzhen; Ding Jingen

doi:10.3969/j.issn.1674-7151.2024.03.015

Abstract：Objective To investigate the correlation between gestational diabetes mellitus(GDM)and glycolipid metabolism indicators in pregnant women.Methods A total of 159 pregnant women admitted to Sanming Second Hospital from October 2020 to October 2023 were selected as research subjects and included in GDM group,in addition 159 healthy pregnant women who underwent prenatal examination in the hospital during the same period were selected as control group.The level of hemoglobin(Hb)was detected using a fully automated blood analyzer and flow cytometry.The levels of blood lipid indicators were detected using a fully automated biochemical analyzer.The levels of high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)were detected using direct method,and the levels of total cholesterol(TC)and triacylglycerol(TG)were detected using oxidase method.The level of glycosylated hemoglobin(HbA1c)was detected using a fully automated HbA1c analyzer and high-performance liquid chromatography.The differences of above indicators between two groups were compared.Spearman correlation analysis was applied to explore the correlation between different indicators and GDM.Results The levels of Hb and HDL-C in GDM group were lower than those in control group,while the levels of TC,TG,LDL-C and HbA1C were higher than those in control group,with statistically significant differences[Hb(g/L):60.00±8.62 vs.142.02±8.50;HDL-C(mmol/L):1.66±0.03 vs.1.80±0.05;TC(mmol/L):6.27±0.21 vs.3.95±0.10;TG(mmol/L):3.06±0.10 vs.2.20±0.05;LDL-C(mmol/L):2.87±0.05 vs.2.25±0.02;HbA1c:0.062±0.006 vs.0.053±0.005;all P＜0.05].TC,TG and LDL-C were moderately positively correlated with GDM(r values were 0.397,0.290 and 0.509,respectively,and P values were 0.001,0.014 and＜0.001,respectively).HDL-C and Hb were moderately negatively correlated with GDM(r values were-0.394 and-0.294,respectively,and P values were 0.001 and 0.013,respectively).Conclusions The elevated levels of HbA1c,TC,LDL-C,as well as the decreased levels of HDL-C and Hb,are considered to be contributing factors to GDM.Monitoring and managing the levels of Hb,blood lipid indicators and HbA1c during pregnancy is of great significance for prevention of GDM,and further research is needed on the potential mechanisms and intervention measures of GDM.