Effects of serum inflammatory indexes on progression of lower urinary tract symptoms in patients with benign prostatic hyperplasia

Zhang Zhen; Yue Ruina; Sun Yingying; He Ming

doi:10.3969/j.issn.1674-7151.2024.03.012

Abstract：Objective To explore the potential impact of serum inflammatory indexes on the progression of lower urinary tract symptoms in patients with benign prostatic hyperplasia(BPH).Methods The 120 patients diagnosed with BPH admitted in Ordos Hospital of Traditional Chinese Medicine from January 2022 to January 2023 were included in study group.Additionally,120 healthy male patients undergoing physical examination during the same period were selected as control group.All patients were tested for serum biochemical indicators[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and procalcitonin(PCT)],and prostate volume and international prostate symptom score(IPSS)were measured and recorded.The correlation between hs-CRP,IL-6,PCT and prostate volume,IPSS score was assessed using Pearson correlation analysis.Results The levels of hs-CRP,IL-6,PCT,prostate volume and IPSS score in study group were higher than those in control group[hs-CRP(mg/L):12.33±1.37 vs.2.08±0.20;IL-6(ng/L):135.86±11.21 vs.6.13±1.46;PCT(μg/L):0.59±0.39 vs.0.03±0.01;prostate volume(mL):44.59±8.77 vs.24.08±5.23;IPSS score(points):18.53±5.12 vs.12.02±2.97;all P＜0.05].Pearson correlation analysis showed that hs-CRP,IL-6 and PCT were positively correlated with prostate volume and IPSS score(prostate volume:r values were 0.525,0.438 and 0.511,P values were 0.013,0.028 and 0.020;IPSS score:r values were 0.356,0.428 and 0.522,P values were 0.032,0.030 and 0.016).Conclusions There is a significant positive correlation between hs-CRP,IL-6,PCT and the severity of lower urinary tract symptoms in patients with BPH.The markers may help for the early identification of symptoms severity in BPH patients,offering new possibilities for individualized treatment and intervention.