Diagnostic value of combined detection of inflammatory markers for bronchopneumonia

Shen Qiong; Fan Yuanwei

doi:10.3969/j.issn.1674-7151.2024.03.010

Abstract：Objective To investigate the clinical significance of combined detection of inflammatory markers in the diagnosis and disease assessment of patients with bronchopneumonia.Methods A total of 80 patients suffering from bronchopneumonia and treated in Xinyi Hospital of Traditional Chinese Medicine from March 2023 to March 2024 were chosen and incorporated into the bronchopneumonia group.The patients were divided into mild group(69 cases)and severe group(11 cases)according to the severity of symptoms.In addition,80 healthy patients during the same period were selected as control group.The levels of procalcitonin(PCT)and interleukin-6(IL-6)were detected by chemiluminescence assay,and the level of hypersensitive C-reactive protein(hs-CRP)was detected by immunoturbidimetric method.The diagnostic efficacy of each index on bronchopneumonia and its relationship with the severity of disease were analyzed by calculating the sensitivity,specificity,accuracy,negative predictive value and positive predictive value.Results The levels of PCT,hs-CRP and IL-6 in bronchopneumonia group were significantly higher than those in control group[PCT(μg/L):0.25±0.18 vs.0.03±0.02;hs-CRP(mg/L):33.59±8.57 vs.4.16±2.83;IL-6(ng/L):73.03±12.06 vs.2.97±0.47;all P＜0.05].The levels of PCT,hs-CRP and IL-6 in patients with severe bronchopneumonia were significantly higher than those in mild group[PCT(μg/L):0.27±0.15 vs.0.11±0.09;hs-CRP(mg/L):35.03±29.88 vs.15.53±13.01;IL-6(ng/L):75.82±13.06 vs.39.77±4.69;all P＜0.05].The sensitivity,specificity,accuracy,negative predictive value and positive predictive value of PCT,hs-CRP and IL-6 combined detection were 92.18%,88.02%,97.29%,84.39%and 94.11%,respectively,which were significantly higher than those of single index detection(those of PCT were 90.71%,56.08%,83.04%,69.39%and 84.97%,respectively;those of hs-CRP were 89.92%,59.83%,77.98%,76.85%and 86.22%,respectively;those of IL-6 were 91.05%,55.71%,86.92%,62.93%and 83.59%,respectively;all P＜0.05).Conclusion Combined detection of PCT,hs-CRP and IL-6 in patients with bronchopneumonia could provide reliable basis for disease diagnosis and is correlated with the severity of disease.