Correlation and detection value of NLR and blood clotting four items with severity of intrahepatic cholestasis of pregnancy
Pan Weijie
Cheng Fu'an
Li Wanying
Lin Bingzhu
Abstract：Objective To analyze the correlation and detection value of neutrophil to lymphocyte ratio(NLR)and blood clotting four items with the severity of intrahepatic cholestasis of pregnancy(ICP).Methods From June 2023 to June 2024,the clinical data of pregnant women in maternity department of Yunfu Maternal and Child Health Hospital were collected,among them 120 pregnant women with ICP were selected as ICP group.According to severity of condition,they were divided into mild group(33 cases),moderate group(56 cases)and severe group(31 cases),and 120 healthy pregnant women were selected as control group.The levels of NLR and blood clotting four items[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FBG)]were detected.The differences of above indicators between ICP patients and healthy pregnant women,as well as ICP patients with different degrees of illness were compared.Pearson correlation analysis was used to investigate the correlation between NLR and blood clotting four items with the severity of ICP.The positive rates of above indexes in ICP patients were calculated.Results The NLR and FBG levels in ICP group were higher than those in control group,while PT,APTT and TT levels were shorter than those in control group[NLR:4.05±2.36 vs.3.42±1.92;FBG(g/L):5.03±0.86 vs.3.51±0.65;PT(s):10.76±1.44 vs.13.41±1.63;APTT(s):28.85±3.30 vs.32.07±3.74;TT(s):15.80±1.80 vs.16.20±0.80;all P＜0.05].The NLR and FBG levels of severe group were higher than those of mild and moderate ICP groups,while PT,APTT and TT levels were shorter than those of mild and moderate groups,with significant differences.The Pearson correlation analysis showed that NLR and FBG were positively correlated with the severity of ICP,while PT,APTT and TT were negatively correlated with the severity of ICP(r values were 0.651,0.619,-0.631,-0.672,-0.653,all P＜0.001).The positive rates of NLR,PT,APTT,TT and FBG in ICP patients were 84.17%,89.17%,87.50%,90.83%and 91.67%,respectively.Conclusion Pregnant women with ICP have higher levels of NLR and abnormal coagulation function,which could be combined with NLR and coagulation to evaluate the severity of the condition.
Keywords：Intrahepatic cholestasis of pregnancyNeutrophil to lymphocyte ratioBlood clotting four items
Publication Date：2024-09-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 222-224 )