Diagnostic value of urinary albumin,immunoglobulin G and β2 microglobulin in elderly diabetic patients

Zhao Zhongfeng

doi:10.3969/j.issn.1674-7151.2024.03.006

Abstract：Objective To explore the application value of urinary albumin,immunoglobulin G(IgG)and β2 microglobulin detection in elderly diabetic patients.Methods The 120 elderly patients with type 2 diabetes admitted to Jinan Integrated Traditional Chinese and Western Medicine Hospital from January 2023 to January 2024 were selected as research objects.According to whether the patients had diabetes nephropathy,they were divided into diabetes nephropathy group(31 cases)and simple diabetes group(89 cases).In addition,100 healthy individuals who underwent physical examinations in the same period of the hospital were selected as control group.The urine and blood samples from each group were collected for biochemical testing,the urine analyzer was used to detect urinary albumin and IgG,and the β2 microglobulin assay kit was used to detect serum β2 microglobulin.The differences in the levels of above indicators among each group were compared.Spearman correlation analysis was used to analyze the correlation between urinary albumin,urinary IgG,serum β2 microglobulin and diabetes nephropathy.The diagnostic results of urinary albumin,urinary IgG and serum β2 microglobulin for diabetes nephropathy were compared.Results The levels of urinary albumin,urinary IgG and serum β2 microglobulin in diabetes nephropathy group were significantly higher than those in simple diabetes group and control group[urinary albumin(mg/L):41.57±9.20 vs.29.03±5.62,18.74±2.95;urinary IgG(mg/L):174.57±25.60 vs.146.43±20.17,103.05±14.29;serum β2 microglobulin(mg/L):3.78±0.96 vs.2.09±0.54,1.40±0.36;all P＜0.05],and the levels of urinary albumin,urinary IgG and serum β2 microglobulin in simple diabetes group were significantly higher than those in control group(all P＜0.05).Urinary albumin,urinary IgG,and serum β2 microglobulin were positively correlated with the occurrence of diabetes nephropathy(r values were 0.854,0.832 and 0.879,P values were 0.003,0.004 and 0.002).The sensitivity and negative predictive value of combined detection of urinary albumin,urinary IgG and serum β2 microglobulin in the diagnosis of diabetes nephropathy were 96.77%and 98.82%,respectively,which were significantly higher than those of single detection of each index.However,the specificity,accuracy and positive predictive value of combined detection were 94.38%,95.00%and 85.71%,and there was no statistical difference between combined and single detection.Conclusions The levels of urine albumin,urinary IgG and serum β2 microglobulin are generally increased in elderly patients with type 2 diabetes,especially in patients with diabetic nephropathy,which is more obvious.Combined detection of different indicators has good diagnostic value for diabetic nephropathy.