Correlation between maternal carbohydrate antigen 125 during pregnancy and immune test results and some biochemical indicators

Li Weiwei

doi:10.3969/j.issn.1674-7151.2024.02.020

Abstract：Objective To analyze the correlation between carbohydrate antigen 125(CA125)during pregnancy and immune test results and some biochemical indicators.Methods The 372 pregnant women who received immune index tests in Pingyi County People's Hospital from January 2022 to January 2023 were selected as research subjects.The observation group consisted of 252 pregnant women with positive immune test results,and the control group consisted of 120 pregnant women with normal immune test results.The immune test results of observation group of parturients were discussed,the levels of CA125,creatinine(Cr),blood urea nitrogen(BUN)and blood glucose(Glu)in each group were compared,and the correlation between CA125 during pregnancy and immune test indicators and some biochemical indicators was discussed.Results In observation group,126 cases were positive for hepatitis B surface antigen(HBsAg positive group),78 cases were positive for hepatitis C antibody(anti-HCV positive group),48 cases were positive for Treponema pallidum antibody(TP antibody positive group),and no positive human immunodeficiency virus(HIV-1/2)antibody was detected.The CA125 levels in HBsAg positive group,anti-HCV positive group and TP antibody positive group were higher than those in control group,while Cr,BUN and Glu levels were lower than those in control group[CA125(kU/L):82.97±12.58,74.67±7.87,70.12±5.24 vs.13.57±2.12;Cr(μmol/L):41.98±2.53,44.12±2.47,44.37±2.54 vs.53.24±2.64;BUN(mmol/L):2.75±0.42,2.68±0.53,2.74±0.55 vs.4.57±1.16;Glu(mmol/L):4.34±1.04,4.21±1.01,4.64±0.94 vs.5.12±1.07;all P<0.05].The changes in CA125 during pregnancy were positively correlated with HBsAg positivity,anti-HCV positivity,TP antibody positivity and BUN(r values were 0.513,0.462,0.314,0.347,P values were 0.012,0.017,0.025,0.022).Conclusion The determination of CA125 combined with immune test results and biochemical indicators in pregnant women could effectively evaluate the risk of AIDS,syphilis,hepatitis B,hepatitis C and other diseases,and promote prevention and treatment.