Application of combined detection of tumor markers in diagnosis of lung malignant tumors
Wang Nengyi
Zhao Feng
Jia Kaiying
Xue Junyu
Abstract：Objective To study the application of combined detection of tumor markers in the diagnosis of lung malignant tumors.Methods A total of 92 patients with pulmonary malignancies and 90 healthy subjects treated in Zibo Municipal Hospital from February 2020 to February 2023 were selected as research objects,and included into disease group and control group,respectively.Electrochemiluminescence immunoassay was applied to detecting serum carcinoembryonic antigen(CEA),neuron specific enolase(NSE)and cytokeratin 19 fragment antigen 21-1(CYFRA21-1)in two groups and patients with different types of lung malignancies.The receiver operator characteristic(ROC)curve was drawn and the area under ROC curve(AUC)was calculated to compare the diagnostic efficacy of the above indicators for lung malignant tumors,both individually and in combination.Results The levels of CEA,NSE and CYFRA21-1 in disease group were higher than those in control group[CEA(μg/L):5.06(2.40,9.83)vs.2.16(1.58,2.69);NSE(μg/L):15.83(12.52,21.22)vs.12.76(11.65,14.00);CYFRA21-1(μg/L):3.30(2.02,6.55)vs.2.29(1.80,3.10);all P<0.05].In disease group,the CEA level in patients with adenocarcinoma was higher than those in patients with lung squamous cell carcinoma and small cell lung carcinoma[μg/L:8.40(3.88,13.41)vs.3.33(2.22,6.23),3.46(2.24,6.25),both P<0.05].The NSE level in patients with small cell lung carcinoma was higher than those in patients with adenocarcinoma and squamous cell lung carcinoma[μg/L:22.74(14.69,40.04)vs.15.11(12.60,19.52),13.08(11.81,16.90),both P<0.05].The CYFRA21-1 level in patients with lung squamous cell carcinoma was higher than those in patients with lung adenocarcinoma and small cell lung carcinoma[μg/L:5.63(3.29,10.12)vs.2.93(2.05,8.58),2.61(1.81,4.32),both P<0.05].There was no statistically significant difference in the positive rate of tumor markers in patients with different types of lung malignant tumors.The positive rate of combined detection in patients with adenocarcinoma was higher than those of NSE and CYFRA21-1 alone(84.21%vs.39.47%,44.74%,both P<0.05),while the positive rate of combined detection in patients with squamous cell lung carcinoma was higher than those of CEA and NSE alone(87.50%vs.33.33%,29.17%,both P<0.05).The positive rate of combined detection in patients with small cell lung carcinoma was higher than those of CEA and CYFRA21-1 alone(86.67%vs.33.33%,36.67%,both P<0.05).Compared with single detection,the diagnostic efficiency of CEA,NSE and CYFRA21-1 combined detection was the highest,AUC was 0.907 and 95%confidence interval(95%CI)was 0.858-0.957.Conclusion The combined detection of CEA,NSE and CYFRA21-1 in the diagnosis of lung malignant tumors is beneficial for clarifying the pathological type,improving the diagnostic rate,and contributing to the improvement of clinical diagnosis and treatment level.
Keywords：Malignant lung tumorTumor markerDiagnosis
Publication Date：2024-06-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 169-172 )