Effect of magnetic resonance imaging combined with cerebrospinal fluid lactate dehydrogenase and C-reactive protein detection on clinical diagnosis and treatment of neonatal suppurative meningitis
Xue Zhibin
Chen Liqing
Lin Haibin
Tang Kaizhi
Abstract：Objective To analyze the effect of magnetic resonance imaging(MRI)combined with cerebrospinal fluid lactate dehydrogenase(LDH)and C-reactive protein(CRP)detection on the clinical diagnosis and treatment of neonatal suppurative meningitis.Methods Totally 30 children with neonatal suppurative meningitis treated in Affiliated Hospital of Putian University from June 2020 to May 2023 were included in observation group,and 30 cases of non-central nervous system infection(including neonatal asphyxia and neonatal hypoxic-ischemic encephalopathy)during the same period were included in control group.All the children underwent MRI examination,and the abnormal rates of the two groups were compared.Receiver operator characteristic(ROC)curve was plotted and the area under ROC curve(AUC)was calculated to evaluate the efficacy of MRI combined with cerebrospinal fluid LDH and CRP in the diagnosis of neonatal suppurative meningitis.Results In observation group,the abnormal rate of MRI was significantly higher than that in control group(100.00%vs.36.67%,P<0.05),and the levels of LDH and CRP in cerebrospinal fluid were significantly higher than those in control group,with statistical significances[LDH(U/L):41.57±4.80 vs.37.55±4.49;CRP(mg/L):7.83±2.49 vs.5.27±1.68;both P<0.05].ROC curve analysis showed that the AUC of MRI,cerebrospinal fluid LDH and CRP in diagnosing neonatal suppurative meningitis was 0.817[95%confidence interval(95%CI)was 0.703-0.931],0.737(95%CI was 0.609-0.866)and 0.793(95%CI was 0.676-0.909),respectively,all of which had certain diagnostic values.The AUC of combined detection of all indicators was 0.843(95%CI was 0.744-0.943),and the diagnostic value was higher than the individual application of each indicator.Conclusion MRI combined with cerebrospinal fluid LDH and CRP has high diagnostic value for neonatal suppurative meningitis,which could effectively guide clinical diagnosis and treatment.
Keywords：Neonatal purulent meningitisMagnetic resonance imagingCerebrospinal fluid lactate dehydrogenaseC-reactive protein
Publication Date：2024-06-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 112-115 )