Application of blood cell count and inflammatory indicators in diagnosis of pulmonary tuberculosis complicated with pulmonary infection

Li Ting; Zhao Ruoxi; Ma Zhiyong; Ma Xiao; Li Meimei; Sun Ranran

doi:10.3969/j.issn.1674-7151.2024.02.002

Abstract：Objective To explore the diagnostic value of blood cell count and inflammatory indicators in patients with pulmonary tuberculosis complicated with pulmonary infection.Methods The clinical data of 231 patients diagnosed with pulmonary tuberculosis admitted to Cangzhou Third Hospital from January 2022 to June 2023 were collected,and the patients were divided into positive group(117 cases)and control group(114 cases)based on presence of pulmonary bacterial infection.Among them,105 cases had normal white blood cell count(WBC)and 108 cases had decreased lymphocyte count(LYM).The levels of neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR),platelet to lymphocyte ratio(PLR),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and procalcitonin(PCT)between two groups were compared.The receiver operator characteristic(ROC)curve was drawn and the area under ROC curve(AUC)was calculated to evaluate the diagnostic efficacy of each indicator.Results The levels of NLR,MLR,PLR,ESR,CRP and PCT in positive group were higher than those in control group[NLR:4.27(2.67,8.38)vs.2.90(1.89,4.42);MLR:0.52(0.32,0.85)vs.0.31(0.21,0.47);PLR:216.67(143.19,342.63)vs.177.70(124.90,281.89);ESR(mm/h):24.50(10.00,41.50)vs.14.50(4.75,28.25);CRP(mg/L):31.20(13.28,90.03)vs.11.30(2.45,39.15);PCT(μg/L):0.10(0.10,0.45)vs.0.10(0.10,0.16);all P<0.05].In patients with normal WBC and those with decreased LYM,the AUC of all indicators was>0.5.Conclusion The diagnostic value of NLR,MLR and PLR for pulmonary tuberculosis combined with pulmonary infection is superior to ESR,CRP and PCT,and they are simple,fast and cost-effective early auxiliary diagnostic indicators.