Distribution and drug resistance of pathogenic bacteria in middle stage urinary culture of patients with urinary infection

Xu Shizhi

doi:10.3969/j.issn.1674-7151.2024.01.012

Abstract：Objective To analyze the distribution and drug resistance of pathogenic bacteria in middle stage urinary culture of patients with urinary tract infection(UTI).Methods The 150 cases of UTI patients admitted to the First People's Hospital of Tancheng County from October 2022 to February 2023 were selected as research objects.The middle stage urine samples were collected for pathogen culture and drug resistance test.The department distribution,pathogen culture and drug resistance test results of UTI patients were analyzed.Results Among the 150 UTI patients,58 cases(38.67%)came from urology department,34 cases(22.67%)from nephrology department,and 21 cases(14.00%)from intensive care unit(ICU).A total of 163 strains of pathogenic bacteria were isolated from the middle stage urine samples provided by 150 patients with UTI,including 108 strains of Gram negative(G-)bacteria(66.26%),42 strains of Gram positive(G+)bacteria(25.77%),and 13 strains of fungi(7.98%).The G-bacteria were mainly Escherichia coli(63.89%)and Klebsiella pneumoniae(17.59%),while the G-bacteria were mainly Enterococcus faecalis(47.42%)and Enterococcus faecium(19.05%).Escherichia coli had high resistance to ampicillin,norfloxacin and compound sulfamethoxazole(95.65%,86.96%and 52.17%).Klebsiella pneumoniae had high resistance to ampicillin and norfloxacin(100.00%and 68.42%),while Enterococcus faecalis had high resistance to erythromycin,furantoin and vancomycin(52.38%,90.48%and 57.14%).Enterococcus faecium had extremely high resistance to ampicillin,ciprofloxacin,levofloxacin,erythromycin,penicillin and vancomycin,all reaching 100.00%.Conclusions The main pathogens of UTI are G-bacteria,among which Escherichia coli and Klebsiella pneumoniae are the most common.Different pathogens have different drug resistance.It is recommended to choose antibiotics based on the results of pathogen resistance test during the treatment process to improve the treatment effect.