Clinical significance of mismatch repair deficiency in colorectal cancer tissue
Sun Hao
Abstract：Objective To analyze the relationship between mismatch repair deficiency(dMMR)and clinical pathological characteristics of colorectal cancer,and explore the clinical significance of dMMR in diagnosis and treatment of colorectal cancer.Methods The clinical and pathological data of 212 patients with colon and rectal cancer undergoing surgical treatment in gastroenterology department of Jining First People's Hospital from December 2021 to July 2023 were collected,and the correlation of dMMR and gender,age,degree of differentiation,TNM stage,T stage,N stage,presence of vascular cancer thrombus,presence of nerve invasion,tumor location and histological type were analyzed.Results Among 212 patients,there were 12 cases(5.66%)with dMMR.Among the 32 patients with right colon cancer,there were 4 cases(12.50%)with dMMR.Among 60 patients with left colon cancer,only 6 cases(10.00%)had dMMR,while among 120 patients with rectal cancer,2 cases(1.67%)had dMMR.The differences were statistically significant(P＜0.05).dMMR was not associated with gender,age,degree of differentiation,TNM stage,T stage,N stage,presence of vascular cancer thrombus or presence of nerve invasion in colorectal cancer patients,but related to tumor location and histological type.The incidence of dMMR was higher in right colon cancer tissue and mucinous adenocarcinoma tissue.Conclusion The difference in incidence of dMMR among colorectal cancer patients is statistically significant,and dMMR detection could help make personalized and accurate diagnosis and treatment plans for patients and determine prognosis.
Keywords：Colorectal cancerMismatch repair proteinClinicopathological characteristics
Publication Date：2024-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 44-46 )