Diagnostic value of liver function indexes detection in biochemical tests for patients with cirrhosis
Hao Kuandi
Abstract：Objective To investigate the diagnostic value of liver function indexes detection in biochemical tests for patients with liver cirrhosis.Methods The 300 patients with liver cirrhosis who received medical treatment in Pingyi County People's Hospital from July 2020 to July 2022 were included in cirrhosis group,200 patients with chronic hepatitis B were included in hepatitis B group,and 300 healthy examiners who underwent physical examination in the hospital during the same period were included in healthy control group.According to Child-Pugh classification,the patients in cirrhosis group were divided into grade A group(149 cases),grade B group(97 cases)and grade C group(54 cases),respectively.The levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkaline phosphatase(ALP)and cholinesterase(CHE)were determined by automatic biochemical analyzer,and the levels of albumin(ALB),total protein(TP)and total bilirubin(TBil)were determined by colorimetry.The levels of above indicators in each group were compared.Results The levels of AST,ALT,ALP and TBil in cirrhosis group were higher than those in hepatitis B group and healthy control group,and the levels of CHE,ALB and TP in cirrhosis group were lower than those in hepatitis B group and healthy control group[AST(U/L):58.64±8.13 vs.45.36±6.08,20.35±2.17;ALT(U/L):65.20±5.24 vs.54.29±4.83,15.46±2.05;ALP(U/L):189.50±10.51 vs.171.35±7.44,72.65±5.56;TBil(μmol/L):94.55±9.11 vs.84.56±7.36,10.95±1.42;CHE(U/L):2119.43±76.80 vs.3245.52±197.26,7125.65±228.95;ALB(g/L):19.26±1.82 vs.27.91±2.65,42.54±4.28;TP(g/L):38.29±2.10 vs.51.42±2.84,73.72±4.31;all P＜0.05].In cirrhosis group,the levels of AST,ALT,ALP and TBil of Child-Pugh grade C patients were higher than those of group B and group A patients,and the levels of CHE,ALB and TP were lower than those of grade B and grade A patients[AST(U/L):72.04±9.15 vs.55.16±7.92,48.72±7.35;ALT(U/L):75.77±5.77 vs.62.54±5.13,57.29±4.82;ALP(U/L):201.56±11.72 vs.188.69±10.06,178.25±9.75;TBil(μmol/L):149.20±10.56 vs.74.59±8.95,59.86±7.82;CHE(U/L):1342.72±65.28 vs.1879.54±79.14,3136.03±85.98;ALB(g/L):17.29±1.22 vs.18.47±1.59,22.02±2.65;TP(g/L):33.54±1.31 vs.37.77±2.20,43.56±2.79,all P＜0.05].The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of combined detection of liver function indexes for the diagnosis of liver cirrhosis were 96.33%,99.00%,97.40%,99.31%and 94.74%,respectively.Conclusion The value of combined detection of liver function indicators in biochemical test for the diagnosis of liver cirrhosis is high,and it could be used for differentiation from chronic hepatitis B.
Keywords：Liver cirrhosisBiochemical testLiver functionDiagnosis
Publication Date：2024-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 40-43 )