Application of combined detection of fasting blood glucose and blood lipid indexes in biochemical examination of patients with diabetes mellitus

Meng Jie; Zhang Liyuan

doi:10.3969/j.issn.1674-7151.2024.01.007

Abstract：Objective To investigate the application of combined detection of fasting blood glucose(FBG)and blood lipid indexes in biochemical test of patients with diabetes mellitus.Methods The 1000 patients with diabetes mellitus who were treated in the Second People's Hospital Liaocheng from July 2020 to July 2022 were selected as research objects and included in observation group,and 1000 healthy physical examiners during the same period were included in control group.Biochemical tests were performed in two groups.The level of FBG was determined by hexokinase method,the levels of total cholesterol(TC)and triglyceride(TG)were determined by oxidase method,and the levels of high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)were determined using direct detection method.The detection results of the above indicators between two groups were compared,the positive rates of individual and combined detection for each indicator were calculated and compared,and the correlation between FBG and blood lipid indicators was analyzed using Pearson coefficient analysis.Results The levels of FBG,TC,TG and LDL-C in observation group were significantly higher than those in control group,while the level of HDL-C was significantly lower than that in control group[FBG(mmol/L):8.56±1.28 vs.5.06±0.33,TC(mmol/L):6.31±0.72 vs.4.20±0.47,TG(mmol/L):2.80±0.51 vs.0.84±0.20,LDL-C(mmol/L):3.97±0.48 vs.1.07±0.29,HDL-C(mmol/L):0.78±0.13 vs.1.40±0.30,all P＜0.05].The positive rates of FBG,blood lipid indexes and combined detection in observation group were significantly higher than those in control group(FBG:89.70%vs.2.50%;blood lipid indexes:75.90%vs.10.60%;combined detection:98.60%vs.0.70%;all P＜0.05),and the positive rate of combined detection in observation group was significantly higher than those of single detection of FBG and blood lipid indexes(98.60%vs.89.70%,75.90%,both P＜0.05).The level of FBG in observation group was negatively correlated with the levels of TC,TG and LDL-C(r values were-0.586,-0.411 and-0.429,P values were all 0.001),and the level of FBG was positively correlated with HDL-C(r value was 0.947,P value was 0.001).Conclusions The combined detection of FBG and blood lipid indexes could improve the diagnostic accuracy of diabetes mellitus.